@article{Gulliver:2018:10.1016/j.envint.2018.01.017,
author = {Gulliver, J and Elliott, P and Hansell, A and Cai, Y and McCrea, A and Garwood, K and Fecht, D and Briggs, D},
doi = {10.1016/j.envint.2018.01.017},
journal = {Environment International},
pages = {10--19},
title = {Local- and regional-scale air pollution modelling (PM10) and exposure assessment for pregnancy trimesters, infancy, and childhood to age 15 years: Avon Longitudinal Study of Parents And Children (ALSPAC).},
url = {http://dx.doi.org/10.1016/j.envint.2018.01.017},
volume = {113},
year = {2018}
}

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TY  - JOUR
AB  - We established air pollution modelling to study particle (PM10) exposures during pregnancy and infancy (1990–1993) through childhood and adolescence up to age ~15years (1991–2008) for the Avon Longitudinal Study of Parents And Children (ALSPAC) birth cohort. For pregnancy trimesters and infancy (birth to 6months; 7 to 12months) we used local (ADMS-Urban) and regional/long-range (NAME-III) air pollution models, with a model constant for local, non-anthropogenic sources. For longer exposure periods (annually and the average of birth to age ~8 and to age ~15years to coincide with relevant follow-up clinics) we assessed spatial contrasts in local sources of PM10 with a yearly-varying concentration for all background sources. We modelled PM10 (μg/m3) for 36,986 address locations over 19years and then accounted for changes in address in calculating exposures for different periods: trimesters/infancy (n=11,929); each year of life to age ~15 (n=10,383). Intra-subject exposure contrasts were largest between pregnancy trimesters (5th to 95th centile: 24.4–37.3μg/m3) and mostly related to temporal variability in regional/long-range PM10. PM10 exposures fell on average by 11.6μg/m3 from first year of life (mean concentration=31.2μg/m3) to age ~15 (mean=19.6μg/m3), and 5.4μg/m3 between follow-up clinics (age ~8 to age ~15). Spatial contrasts in 8-year average PM10 exposures (5th to 95th centile) were relatively low: 25.4–30.0μg/m3 to age ~8years and 20.7–23.9μg/m3 from age ~8 to age ~15years. The contribution of local sources to total PM10 was 18.5%–19.5% during pregnancy and infancy, and 14.4%–17.0% for periods leading up to follow-up clinics. Main roads within the study area contributed on average ~3.0% to total PM10 exposures in all periods; 9.5% of address locations were within 50m of a main road. Exposure estimates will be used in a number of planned epidemiological studies.
AU  - Gulliver,J
AU  - Elliott,P
AU  - Hansell,A
AU  - Cai,Y
AU  - McCrea,A
AU  - Garwood,K
AU  - Fecht,D
AU  - Briggs,D
DO  - 10.1016/j.envint.2018.01.017
EP  - 19
PY  - 2018///
SN  - 0160-4120
SP  - 10
TI  - Local- and regional-scale air pollution modelling (PM10) and exposure assessment for pregnancy trimesters, infancy, and childhood to age 15 years: Avon Longitudinal Study of Parents And Children (ALSPAC).
T2  - Environment International
UR  - http://dx.doi.org/10.1016/j.envint.2018.01.017
UR  - http://hdl.handle.net/10044/1/56288
VL  - 113
ER  - 

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