@article{Cyras:2021:10.3233/aac-200523,
author = {Cyras, K and Oliveira, T and Karamlou, M and Toni, F},
doi = {10.3233/aac-200523},
journal = {Argument and Computation},
pages = {149--189},
title = {Assumption-based argumentation with preferences and goals for patient-centric reasoning with interacting clinical guidelines},
url = {http://dx.doi.org/10.3233/aac-200523},
volume = {12},
year = {2021}
}

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TY  - JOUR
AB  - A paramount, yet unresolved issue in personalised medicine is that of automated reasoning with clinical guidelines in multimorbidity settings. This entails enabling machines to use computerised generic clinical guideline recommendations and patient-specific information to yield patient-tailored recommendations where interactions arising due to multimorbidities are resolved. This problem is further complicated by patient management desiderata, in particular the need to account for patient-centric goals as well as preferences of various parties involved. We propose to solve this problem of automated reasoning with interacting guideline recommendations in the context of a given patient by means of computational argumentation. In particular, we advance a structured argumentation formalism ABA+G (short for Assumption-Based Argumentation with Preferences (ABA+) and Goals) for integrating and reasoning with information about recommendations, interactions, patient’s state, preferences and prioritised goals. ABA+G combines assumption-based reasoning with preferences and goal-driven selection among reasoning outcomes. Specifically, we assume defeasible applicability of guideline recommendations with the general goal of patient well-being, resolve interactions (conflicts and otherwise undesirable situations) among recommendations based on the state and preferences of the patient, and employ patient-centered goals to suggest interaction-resolving, goal-importance maximising and preference-adhering recommendations. We use a well-established Transition-based Medical Recommendation model for representing guideline recommendations and identifying interactions thereof, and map the components in question, together with the given patient’s state, prioritised goals, and preferences over actions, to ABA+G for automated reasoning. In this, we follow principles of patient management and establish corresponding theoretical properties as well as illustrate our approach in realis
AU  - Cyras,K
AU  - Oliveira,T
AU  - Karamlou,M
AU  - Toni,F
DO  - 10.3233/aac-200523
EP  - 189
PY  - 2021///
SN  - 1946-2166
SP  - 149
TI  - Assumption-based argumentation with preferences and goals for patient-centric reasoning with interacting clinical guidelines
T2  - Argument and Computation
UR  - http://dx.doi.org/10.3233/aac-200523
UR  - http://hdl.handle.net/10044/1/83543
VL  - 12
ER  - 

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