@article{Herrero:2017:10.1080/10255842.2017.1378352,
author = {Herrero, P and Bondia, J and Oliver, N and Georgiou, P},
doi = {10.1080/10255842.2017.1378352},
journal = {Computer Methods in Biomechanics and Biomedical Engineering},
pages = {1474--1482},
title = {A coordinated control strategy for insulin and glucagon delivery in type 1 diabetes},
url = {http://dx.doi.org/10.1080/10255842.2017.1378352},
volume = {20},
year = {2017}
}

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TY  - JOUR
AB  - Type 1 diabetes is an autoimmune condition characterised by a pancreatic insulin secretion deficit, resulting in high blood glucose concentrations, which can lead to micro- and macrovascular complications. Type 1 diabetes also leads to impaired glucagon production by the pancreatic α-cells, which acts as a counter-regulatory hormone to insulin. A closed-loop system for automatic insulin and glucagon delivery, also referred to as an artificial pancreas, has the potential to reduce the self-management burden of type 1 diabetes and reduce the risk of hypo- and hyperglycemia. To date, bihormonal closed-loop systems for glucagon and insulin delivery have been based on two independent controllers. However, in physiology, the secretion of insulin and glucagon in the body is closely interconnected by paracrine and endocrine associations. In this work, we present a novel biologically-inspired glucose control strategy that accounts for such coordination. An in silico study using an FDA-accepted type 1 simulator was performed to evaluate the proposed coordinated control strategy compared to its non-coordinated counterpart, as well as an insulin-only version of the controller. The proposed coordinated strategy achieves a reduction of hyperglycemia without increasing hypoglycemia, when compared to its non-coordinated counterpart.
AU  - Herrero,P
AU  - Bondia,J
AU  - Oliver,N
AU  - Georgiou,P
DO  - 10.1080/10255842.2017.1378352
EP  - 1482
PY  - 2017///
SN  - 1025-5842
SP  - 1474
TI  - A coordinated control strategy for insulin and glucagon delivery in type 1 diabetes
T2  - Computer Methods in Biomechanics and Biomedical Engineering
UR  - http://dx.doi.org/10.1080/10255842.2017.1378352
UR  - http://hdl.handle.net/10044/1/69814
VL  - 20
ER  - 

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