@article{Woods:2013:10.1109/TBME.2012.2228647,
author = {Woods, SP and Constandinou, TG},
doi = {10.1109/TBME.2012.2228647},
journal = {IEEE Transactions on Biomedical Engineering},
pages = {945--953},
title = {Wireless Capsule Endoscope for Targeted Drug Delivery: Mechanics and Design Considerations},
url = {http://dx.doi.org/10.1109/TBME.2012.2228647},
volume = {60},
year = {2013}
}

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TY  - JOUR
AB  - This paper describes a platform to achieve targeted drug delivery in next generation wireless capsule endoscopy. The platform consists of two highly novel sub-systems: one is a micro-positioning mechanism which can deliver 1ml of targeted medication and the other is a holding mechanism which gives the functionality of resisting peristalsis. The micro-positioning mechanism allows a needle to be positioned within a 22.5 segment of a cylindrical capsule and be extendible by up to 1.5mm outside the capsule body. The mechanism achieves both these functions using only a single micro-motor and occupying a total volume of just 200mm³. The holding mechanism can be deployed diametrically opposite the needle in 1.8s and occupies a volume of just 270mm³. An in-depth analysis of the mechanics is presented and an overview of the requirements necessary to realise a total system integration is discussed. It is envisaged that the targeted drug delivery platform will empower a new breed of capsule micro-robots for therapy in addition to diagnostics for pathologies such as ulcerative colitis and small intestinal Crohn's disease.
AU  - Woods,SP
AU  - Constandinou,TG
DO  - 10.1109/TBME.2012.2228647
EP  - 953
PY  - 2013///
SN  - 0018-9294
SP  - 945
TI  - Wireless Capsule Endoscope for Targeted Drug Delivery: Mechanics and Design Considerations
T2  - IEEE Transactions on Biomedical Engineering
UR  - http://dx.doi.org/10.1109/TBME.2012.2228647
UR  - http://hdl.handle.net/10044/1/10976
UR  - http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=6359797
VL  - 60
ER  - 

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