Cell signalling cascades
This software contains detailed modelling of the single photon response, the quantum bump, of fly photoreceptors. All known components participating in the primary phototransduction process are taken into account, and estimates are given for both the physical and chemical parameters. Both deterministic and stochastic simulations of the photoinduced current are possible using the same software. The code was implemented in Matlab and stored in the Imperial College London repository. It includes a GUI which offers easy access and manipulation of the input parameters and therefore allows for simulations for a vast number of interesting possibilities, such as various mutants, different ionic concentrations, etc. Explanations for all the equations and parameters used are given in Ref. 1.
- Nikolic, K, Loizu, J, Degenaar, P and Toumazou, C. (2010). A stochastic model of the single photon response in Drosophila photoreceptors. Integrative Biology 2: 354–370, DOI: 10.1039/C0IB00031K
- Nikolic, K, Loizu, J and Degenaar, P. (2010). Computational Modelling of the Drosophila Phototransduction Cascade. Biophysical Journal 98(3): 495a–495a, DOI: 10.1016/j.bpj.2009.12.2695
- Nikolic, C and Toumazou, C. (2010). A bio-inspired ultrasensitive imaging chip—Phase one: Design paradigm. Circuits and Systems (ISCAS), Proceedings of 2010 IEEE International Symposium on 30 May - 02 June 2010, ParisIEEE, pp. 345–348, DOI: 10.1109/ISCAS.2010.5537798
- Nikolic K and Loizu J, (2013). Drosophila Photo-transduction Simulator, Journal of Open Research Software, Vol: 1, ISSN: 2049-9647, DOI: 10.5334/503b9b1a69665