Recently improved and perfected by bioengineering researchers, Imperial College's Histocutter provides an excellent solution to multiple imaging requirements. This robotic device expertly constructs high-throughput, high resolution, 3D histological imaging, capturing and aligning thousands of multi-spectral high quality images and making them ready for quantitative analysis and 3D visualisation.
Only a few examples of this type of instrument can be found, and the Histocutter stands apart in its ability to achieve both lateral and axial resolutions that approach 1um. It presents a unique opportunity to perform cutting edge 3D analysis of samples, whatever your requirement.
If you need to create 3D structural information for an entire organ or if your sample is too large or optically dense to image with a confocal microscope. if you need to validate your Micro-CT results with histology-based imaging modality or if you don't have time to cut and stain thousands of sections by hand, then the Histocutter could be for you.
The Histocutter is ideal for conducting studies where optical penetration is limited like in bone and cartilage. Vascular tracers, bone growth indicators (calcein, alizarin red) and en-bloc dyes can be imaged, while unstained tissues can also be seen.
Typical samples include organs, engineered scaffolds seeded with cells, tissue explants and patient biopsies, including cancer biopsies and whole lymph nodes.
Find out more about how the Histocutter has been used in some recent research projects.
You can also find out more about the service we provide.