@article{Jackson:2009,
author = {Jackson, MJ and Wood, NB and Zhao, S and Augst, A and Wolfe, JH and Gedroyc, WMW and Hughes, AD and Thom, SA and Xu, XY},
journal = {Artery Research},
pages = {32--38},
title = {Low wall shear stress predicts subsequent development of wall hypertrophy in lower limb bypass grafts},
url = {http://hdl.handle.net/10044/1/4315},
volume = {3},
year = {2009}
}

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TY  - JOUR
AB  - Background: Venous grafts commonly develop myointimal hyperplasia, which can  lead to stenoses and, ultimately, with expression of adhesion molecules, lumenal occlusion. The  aim of the present study was to investigate whether wall shear stress measured post-operatively  would predict subsequent myointimal hypertrophy in lower limb venous bypass grafts.  Methods: Magnetic resonance imaging and ultrasound were performed in a cohort of patients  following lower limb venous bypass graft surgery for peripheral arterial disease at baseline  (1e2 weeks) and at follow-up (9e12 months). Wall shear stress was determined at baseline using  computational fluid dynamics techniques and intima-media thickness along the length of the graft  was measured by ultrasound at baseline and follow up.  Results: Complete follow-up was possible in eight patients, in whom low wall shear stress at baseline  predicted high intima-media thickness. The relationship between wall shear stress (WSS) and  intima-media thickness (IMT)was curvilinear with IMTincreasing sharply at lower levels ofWSS (IMT  >1.0 mm at <0.3 Pa).  Conclusions: Low wall shear stress is associated with subsequent increase in myointimal thickness  in lower limb venous bypass grafts. This is believed to be the first prospective study in humans to  demonstrate the relationship between low wall shear stress and myointimal thickening and indicates  a likely causative role for lowwall shear stress in the development ofmyointimal hyperplasia.
AU  - Jackson,MJ
AU  - Wood,NB
AU  - Zhao,S
AU  - Augst,A
AU  - Wolfe,JH
AU  - Gedroyc,WMW
AU  - Hughes,AD
AU  - Thom,SA
AU  - Xu,XY
EP  - 38
PY  - 2009///
SN  - 1872-9312
SP  - 32
TI  - Low wall shear stress predicts subsequent development of wall hypertrophy in lower limb bypass grafts
T2  - Artery Research
UR  - http://hdl.handle.net/10044/1/4315
VL  - 3
ER  - 

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