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  • JOURNAL ARTICLE
    Lowry JP, Boutelle MG, Fillenz M, 1997,

    Measurement of brain tissue oxygen at a carbon paste electrode can serve as an index of increases in regional cerebral blood flow

    , JOURNAL OF NEUROSCIENCE METHODS, Vol: 71, Pages: 177-182, ISSN: 0165-0270
  • JOURNAL ARTICLE
    Boutelle MG, Allen H, Hill O, Berners M, John R, Dobson PD, Leigh Pet al., 1996,

    New technologies for amperometric biosensors

    , JOURNAL OF MOLECULAR RECOGNITION, Vol: 9, Pages: 664-671, ISSN: 0952-3499
  • JOURNAL ARTICLE
    Boutelle MG, Fillenz M, 1996,

    Clinical microdialysis: The role of on-line measurement and quantitative microdialysis

    , CLINICAL ASPECTS OF MICRODIALYSIS, Vol: 67, Pages: 13-20, ISSN: 0065-1419
  • CONFERENCE PAPER
    Forsyth R, Fray A, Boutelle M, Fillenz M, Middleditchc C, Burchell Aet al., 1996,

    A role for astrocytes in glucose delivery to neurons?

    , Pages: 360-370, ISSN: 0378-5866

    The present paper examines the possible role of astrocytes in the delivery of glycogen-derived glucose for neuronal metabolism. Such a process would require astrocytic expression of glucose-6-phosphatase. The degree and significance of brain expression of glucose-6-phosphatase (EC 3.1.3.9) has been a subject of controversy. Published immunohistochemical data are consistent with expression of glucose-6-phosphatase by astrocytes, both in vivo and in vitro. In this paper additional confirmation of the expression of glucose-6-phosphatase mRNA in rat brain is presented. Although cultured astrocytes demonstrate glucose-6-phosphatase activity in vitro under assay conditions, there is very limited in vitro evidence that this activity confers a glucose-export capacity on astrocytes. Under most conditions in vitro, lactate export predominates, however this may relate to aspects of the in vitro phenotype. Data relating to astrocytic glucose and lactate export are considered in the context of hypotheses of trafficking by astrocytes of substrates for neur onal metabolism, hypotheses that imply and require compartmentation of these substances, in contrast with current formulations of glucose transport into and within brain that imply no glucose compartmentation. Microdialysis studies of the properties of the brain extracellular fluid (ECF) glucose pool in the freely moving rat were performed seeking evidence of glucose compartmentation. Results of these studies do imply compartmentalisation of brain glucose, and are consistent with a model envisaging the majority of glucose reaching the neuron via the astrocytic intracellular space and the ECF. In addition, such studies provide evidence that rises in ECF glucose concentration are not the direct result of local recruitment of cerebral blood flow, but suggest the influence of intermediate, astrocyte-based mechanisms. Astrocytic glucose-6-phosphatase may permit astrocytes to modulate the transastrocytic flux of glucose to adjacent n

  • JOURNAL ARTICLE
    Fray AE, Forsyth RJ, Boutelle MG, Fillenz Met al., 1996,

    The mechanisms controlling physiologically stimulated changes in rat brain glucose and lactate: A microdialysis study

    , JOURNAL OF PHYSIOLOGY-LONDON, Vol: 496, Pages: 49-57, ISSN: 0022-3751
  • JOURNAL ARTICLE
    Lowry JP, Boutelle MG, ONeill RD, Fillenz Met al., 1996,

    Characterization of carbon paste electrodes in vitro for simultaneous amperometric measurement of changes in oxygen and ascorbic acid concentrations in vivo

    , ANALYST, Vol: 121, Pages: 761-766, ISSN: 0003-2654
  • JOURNAL ARTICLE
    Miele M, Berners M, Boutelle MG, Kusakabe H, Fillenz Met al., 1996,

    The determination of the extracellular concentration of brain glutamate using quantitative microdialysis

    , BRAIN RESEARCH, Vol: 707, Pages: 131-133, ISSN: 0006-8993
  • JOURNAL ARTICLE
    Miele M, Boutelle MG, Fillenz M, 1996,

    The source of physiologically stimulated glutamate efflux from the striatum of conscious rats

    , JOURNAL OF PHYSIOLOGY-LONDON, Vol: 497, Pages: 745-751, ISSN: 0022-3751
  • JOURNAL ARTICLE
    VAHABZADEH A, BOUTELLE MG, FILLENZ M, 1995,

    EFFECTS OF CHANGES IN RAT-BRAIN GLUCOSE ON SEROTONERGIC AND NORADRENERGIC NEURONS

    , EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 7, Pages: 175-179, ISSN: 0953-816X
  • JOURNAL ARTICLE
    WHEELER D, BOUTELLE MG, FILLENZ M, 1995,

    THE ROLE OF N-METHYL-D-ASPARTATE RECEPTORS IN THE REGULATION OF PHYSIOLOGICALLY RELEASED DOPAMINE

    , NEUROSCIENCE, Vol: 65, Pages: 767-774, ISSN: 0306-4522

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