The Royal British Legion

 

The Royal British Legion Centre for Blast Injury Studies (CBIS) at Imperial College London is housed within the leading Department of Bioengineering, attracting outstanding students and researchers from around the world. The Centre is comprised of multidisciplinary collaborations between military medical officers and civilian engineers and scientists that address difficult research issues with a clinically-led approach.

Studying the effects of blast injury develops and advances treatment, rehabilitation and recovery from injury while improving mitigation and promoting understanding of complex trauma. Students will benefit from a highly stimulating environment where they undertake a range of additional training and development opportunities as part of the Centre’s PhD cohort.

Studentships (2018-19)

Funded PhD Opportunities

Please see below for current opportunities. To learn more about the projects listed below, please contact the supervisor(s) associated with the project in which you are interested. 

Details on eligibility and how to apply can be found in the drop down sections below. For any general enquires not covered on these webpages, please contact cbis@imperial.ac.uk

Project titleSupervisor(s)Closing date 
In vitro and in vivo models of inappropriate bone formation Dr Claire Higgins

04 July 2019

Summary of the table's contents

In vitro and in vivo models of inappropriate bone formation

Heterotopic ossification is the inappropriate formation of bone in soft tissues of the body in response to a blast (high energy shockwave induced) event. Work in the centre has focused on separating out the direct effect of the shockwave on cells, with the effect of the systemic response the body has to an injury. Using a shocktube to create single 165kPa shockwaves, we have identified methylation specific changes in gene promoters, which we have correlated with excess bone deposition in an in vitro system. One of these differentially methylated genes is a novel therapeutic target, which we believe can be used to prevent heterotopic ossification. Using ATAC-Sequencing, we have also found chromatin rearrangements in this target which lead to ossification. In this PhD project, we want to use advanced molecular biology approaches to investigate the validity of this therapeutic target, using both in vitro and in vivo models of heterotopic ossification.

Projects: how many studentships are available and for which projects?

We are currently inviting applications for one CBIS studentship position. 

If you are interested in applying for a PhD studentship within the Centre, please go to the below section titled 'Application: am I eligible and, if so, how do I apply?' for further information.

Funding: what does a CBIS studentship cover?

Studentships cover three years of Home-EU tuition fees and provide a 3-year, tax-free stipend at the standard Research Council United Kingdom rate (£16,999 per annum for 2019-20). In addition, a generous allowance is provided for research consumables and conference attendance.

Any non Home-EU applicants will need to show that they can cover the difference between the Home-EU and overseas tuition fee rates.

Application: am I eligible and, if so, how do I apply?

Candidates who meet the College's PhD programme entry requirements are eligible to apply. Entry onto the PhD programme requires an undergraduate degree at 2:1 level or higher and, normally, a master’s degree with merit or higher (or non-UK equivalents) in engineering, or any of the physical sciences or mathematics.

To apply to the CBIS PhD programme please visit the College's admissions webpages to view the instructions. When creating an account on the submission platform, or when starting a new application, select ‘Doctoral’ as the Course Type and then choose ‘Bioengineering Research (CBIS)’ as the Academic Programme. Your application should be submitted no later than 04 July 2019.

Within the “Supporting Documents” area of the online application portal, you will need to upload a personal statement of up to two pages that covers the below points. This should be uploaded in the “Research Proposal” section.

  • Why you want to undertake a PhD within the Centre for Blast Injury Studies;
  • Your reasons for your preferred topic area(s) and supervisor(s);
  • A description of how your experience to date would make you an ideal candidate to undertake a PhD in the Centre.

The deadline for applications is 04 July 2019. After this date, applications will be sent to the supervisors for review. We will then contact you to let you know if you have been shortlisted for interview.  

For general enquiries about CBIS, its activities and opportunities, please contact us at cbis@imperial.ac.uk.

Regular Centre networking activities facilitate collaboration.

Two PhD students, both based in Bioengineering, discuss their research at the most recent CBIS Coffee Morning event, where the Centre's researchers catch up with each other.

CBIS has a range of facilities to enable world-leading research.

CBIS postdoctoral researcher and former PhD student works with the Split Hopkinson Pressure Bar, just one of the Centre's facilities that enables world-leading research.

CBIS PhDs have the opportunity to organise the annual networking event.

CBIS PhD student and military clinician (right) networks at the 2016 Networking and Research Update Event, of which he was a key organising member.

Centre networking events facilitate team building.

New CBIS PhD students, like this one (right), benefit from Centre's networking and team-building events, which enable cohort building.

CBIS PhD students are key parts of building the Centre's networks.

CBIS PhD students contribute to building and participate in the activities of the Centre's networks, like the Surgical Training Network.

Celebrating success

The Centre comes together to celebrate the successes of its researchers, such as when Bioengineering-based PhD student and Centre Veterans Representative won Bronze in the 2016 Rio Paralympics.

CBIS has a range of facilities to enable world-leading research into the area of blast injury.

CBIS postdoctoral researcher and former PhD student works with the AnUBIS (Anti-vehicle Underbelly Blast Injury Simulator), just one of the Centre's facilities that enables world-leading research.

CBIS researchers present their work at national and international events.

CBIS MD(Res) student presents his research and involvement in organising the inaugural Surgical Training Course at the Centre's 2016 Networking and Research Update Event.

CBIS PhD Students preparing for the 2016 Imperial Festival.

CBIS PhD students and military clinicians prepare for the 2016 Imperial Festival, where they share their research with hundreds of members of the public of all ages.

CBIS PhD Students participate in outreach events, like the Imperial Festival

CBIS PhD student and military clinician participates in the 2016 Imperial Festival, a public outreach event that sees thousands of members of the public of all ages visiting the College.

Networking from the start

New CBIS PhD student (left) attends the 2016 Networking and Research Update Event shortly after his arrival to the Centre, showing that networking opportunities are available from the start.

CBIS coffee morning

Collaboration and cohort building go hand in hand, which is why the Centre holds event for its PhD students, postdoctoral researchers and academics to facilitate both.

Back view snapshot of the audience during a presentation at the 2017 Annual Networking and Research Update Event.

Back view snapshot of the audience during a presentation at the 2017 Annual Networking and Research Update Event.

Professor Anthony Bull and MG Barbara Holcomb, Commander of US Army Medical Research & Material command, networking ahead of session 3, titled ‘Rehabilitation and long-term outcomes’.

Professor Anthony Bull and MG Barbara Holcomb, Commander of US Army Medical Research & Material command, networking ahead of session 3, titled ‘Rehabilitation and long-term outcomes’.

A research staff member interacting with guests at the 2017 Imperial Festival.

A research staff member interacting with a guest at the 2017 Imperial Festival.