BibTex format

author = {Ferreira-Martins, J and Howard, J and Al-Khayatt, BM and Shalhoub, J and Sohaib, A and Shun-Shin, M and Novak, P and Leather, R and Sterns, L and Lane, C and Lim, P and Kanagaratnam, P and Peters, N and Francis, D and Sikkel, M},
doi = {10.1111/jce.13745},
journal = {Journal of Cardiovascular Electrophysiology},
pages = {1471--1479},
title = {Outcomes of paroxysmal AF ablation studies are affected more by study design and patient mix than ablation technique},
url = {},
volume = {29},
year = {2018}

RIS format (EndNote, RefMan)

AB - Objective: We tested whether ablation methodology and study design can explain the varying outcomes in terms of AF-free survival at 1 year.Background:There have been numerous paroxysmal AF ablation trials, which are heterogeneous in their use of different ablation techniques and study design. A useful approach to understanding how these factors influence outcome is to dismantle the trials into individual arms and reconstitute them as a large meta-regression.Methods: Data was collected from 66 studies (6941 patients). With freedom from AF as the dependent variable, we performed meta-regression using the individual study arm as the unit.Results: Success rates did not change regardless of the technique used to produce pulmonary vein isolation. Neither were adjunctive lesion sets associated with any improvement in outcome.Studies that included more males and fewer hypertensive patients were found more likely to report better outcomes. ECG method selected to assess outcome also plays an important role. Outcomes were worse in studies that used regular telemonitoring (by 23%, p<0.001) or in patients who had implantable loop recorders (by 21%, p=0.006), rather than less thorough periodic Holter monitoring.Conclusions: Outcomes of AF ablation studies involving pulmonary vein isolation are not affected by the technologies used to produce PVI. Neither do adjunctive lesion sets change the outcome. Achieving high success rates in these studies appears to be dependent more on patient mix and on the thoroughness of AF detection protocols. This should be carefully considered when quoting success rates of AF ablation procedures which are derived from such studies.
AU - Ferreira-Martins,J
AU - Howard,J
AU - Al-Khayatt,BM
AU - Shalhoub,J
AU - Sohaib,A
AU - Shun-Shin,M
AU - Novak,P
AU - Leather,R
AU - Sterns,L
AU - Lane,C
AU - Lim,P
AU - Kanagaratnam,P
AU - Peters,N
AU - Francis,D
AU - Sikkel,M
DO - 10.1111/jce.13745
EP - 1479
PY - 2018///
SN - 1045-3873
SP - 1471
TI - Outcomes of paroxysmal AF ablation studies are affected more by study design and patient mix than ablation technique
T2 - Journal of Cardiovascular Electrophysiology
UR -
UR -
VL - 29
ER -