@article{Michie:2014:10.1371/journal.pone.0107211,
author = {Michie, KA and Boysen, A and Low, HH and Moller-Jensen, J and Loewe, J},
doi = {10.1371/journal.pone.0107211},
journal = {PLoS One},
pages = {1--10},
title = {LeoA, B and C from enterotoxigenic escherichia coli (ETEC) are bacterial dynamins},
url = {http://dx.doi.org/10.1371/journal.pone.0107211},
volume = {9},
year = {2014}
}

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TY  - JOUR
AB  - Escherichia coli (ETEC) strain H10407 contains a GTPase virulence factor, LeoA, which is encoded on a pathogenicity island and has been shown to enhance toxin release, potentially through vesicle secretion. By sequence comparisons and X-ray structure determination we now identify LeoA as a bacterial dynamin-like protein (DLP). Proteins of the dynamin family remodel membranes and were once thought to be restricted to eukaryotes. In ETEC H10407 LeoA localises to the periplasm where it forms a punctate localisation pattern. Bioinformatic analyses of leoA and the two upstream genes leoB and leoC suggest that LeoA works in concert with a second dynamin-like protein, made up of LeoB and LeoC. Disruption of the leoAB genes leads to a reduction in secretion of periplasmic Tat-GFP and outer membrane OmpA. Our data suggest a role for LeoABC dynamin-like proteins in potentiating virulence through membrane vesicle associated toxin secretion.
AU  - Michie,KA
AU  - Boysen,A
AU  - Low,HH
AU  - Moller-Jensen,J
AU  - Loewe,J
DO  - 10.1371/journal.pone.0107211
EP  - 10
PY  - 2014///
SN  - 1932-6203
SP  - 1
TI  - LeoA, B and C from enterotoxigenic escherichia coli (ETEC) are bacterial dynamins
T2  - PLoS One
UR  - http://dx.doi.org/10.1371/journal.pone.0107211
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000342684500075&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107211
UR  - http://hdl.handle.net/10044/1/82081
VL  - 9
ER  - 

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