Imperial pioneers new biological engineering parts
-MIT
-The iGEM competitionBy Danielle Reeves
11 August 2006
A team of students from Imperial College London is attempting to be amongst the first in the world to merge engineering concepts with biology to produce genetically engineered machines. The project constitutes Imperial's entry in the 2006 international Genetically Engineered Machines (iGEM) competition which is running this summer from 1 July for 10 weeks.
The Imperial team, comprising eight
undergraduates from engineering and biology, together with their
advisors, has devised a project in which bacterial DNA is modified
in order to create the worlds first biologically-based stable
oscillator within a population of bacterial cells. An oscillator
generates a recurring waveform, normally of some variable, such as
voltage or the concentration of a substance, plotted against time.
The importance of producing a stable oscillator of this type is
that oscillators are fundamental building blocks in many different
types of systems - both biological and man made. The aim of the
overall iGEM project is to create a catalogue of standard
biologically based parts, which can then be used to create devices
and systems for a range of applications.
The groundbreaking work falls under the banner of synthetic biology; an emerging science which merges engineering approaches with biology. In the long term, synthetic biology could be used to create new materials, new types of sensors, or bio fuels by cell-based processes.
Professor Richard Kitney 
from Imperials Department of
Bioengineering, said: "This research is at the forefront of a new
kind of science, which combines an engineering approach with
complex biological systems to use cells as manufacturing units. The
idea of using biology to build engineering parts, and eventually
devices, is truly revolutionary. This could have an enormous impact
on the way in which devices and materials are constructed."
Alongside Professor Kitney, the competition project is being
carried out under the supervision of Vincent Rouilly and Chueh Loo
Poh from Imperials Department of Bioengineering and Professor Paul Freemont and Dr
David Mann from Imperials Divisions
of Molecular Biosciences and Cell and Molecular Biology.
The Imperial students are using two
distinct cell populations, which form an oscillating system based
on 'predator/prey' dynamics. In this sort of system, there are two
distinct populations of cells, one of which produces 'predator'
molecules and one of which produces molecular 'prey.' The
concentration levels of these two molecules alternately rises and
falls, and it is this repeating cycle which creates the
oscillation. If successful, they will have created a biological
oscillator which can form part of a biologically based device.
Professor Paul Freemont from Imperial's Division of Molecular Biosciences added: "iGEM gives some of our outstanding undergraduate students from the Faculties of Engineering and Natural Sciences the chance to work together in competition with students from other leading international universities. It's a really exciting project as it allows our students to get hands-on experience of research that's never been done before."
Imperial's iGEM team consists of three biologists, three bioengineers, one biochemist and an electrical engineer. They will be competing against 37 other teams from universities around the world, including Harvard and Princeton. The competition will culminate on the weekend of the 3 - 5 November 2006 when the Imperial team travel to MIT to present the results of their work. MIT founded and organise the annual competition. The other British institutions taking part are the University of Cambridge and the University of Edinburgh.
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