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  • Journal article
    Kinnunen KM, Greenwood R, Powell JH, Leech R, Hawkins PC, Bonnelle V, Patel MC, Counsell SJ, Sharp DJet al., 2011,

    White matter damage and cognitive impairment after traumatic brain injury

    , BRAIN, Vol: 134, Pages: 449-463, ISSN: 0006-8950
  • Journal article
    Thomas EL, Collins AL, McCarthy J, Fitzpatrick J, Durighel G, Goldstone AP, Bell JDet al., 2011,

    Estimation of abdominal fat compartments by bioelectrical impedance: the validity of the ViScan measurement system in comparison with MRI (vol 64, pg 525, 2010)

    , EUROPEAN JOURNAL OF CLINICAL NUTRITION, Vol: 65, Pages: 284-284, ISSN: 0954-3007
  • Conference paper
    Deligiannia F, Robinson E, Beckmann CF, Sharp D, Edwards AD, Rueckert Det al., 2011,

    INFERENCE OF FUNCTIONAL CONNECTIVITY FROM DIRECT AND INDIRECT STRUCTURAL BRAIN CONNECTIONS

    , 8th IEEE International Symposium on Biomedical Imaging (ISBI) - From Nano to Macro, Publisher: IEEE, Pages: 849-852, ISSN: 1945-7928
  • Conference paper
    Carroll RW, Tan T, Todd JF, Al-Nahhas A, Bomanji J, Gaze MN, Meeran K, Goldstone APet al., 2011,

    Lutetium-177 DOTATATE Therapy in the Management of Neuroendocrine Tumors

    , 8th Annual ENETS Conference for the Diagnosis and Treatment of Neuroendocine Tumor Disease, Publisher: KARGER, Pages: 19-19, ISSN: 0028-3835
  • Conference paper
    Carroll RW, Martin JL, Tan T, Goldstone AP, Spalding D, Al-Nahhas A, Todd JF, Meeran K, Frilling Aet al., 2011,

    Primary Lymph Node Gastrinoma: A Genuine Entity? Two Case Reports and a Review of the Literature

    , 8th Annual ENETS Conference for the Diagnosis and Treatment of Neuroendocine Tumor Disease, Publisher: KARGER, Pages: 18-19, ISSN: 0028-3835
  • Conference paper
    Deligianni F, Varoquaux G, Thirion B, Robinson E, Sharp DJ, Edwards AD, Rueckert Det al., 2011,

    A Probabilistic Framework to Infer Brain Functional Connectivity from Anatomical Connections

    , 22nd International Conference on Information Processing in Medical Imaging (IPMI), Publisher: SPRINGER-VERLAG BERLIN, Pages: 296-307, ISSN: 0302-9743
  • Journal article
    Sharp DJ, Beckmann CF, Greenwood RJ, Kinnunen KM, Bonnelle V, De BX, Powell J, Counsell SJ, Patel M, Leech Ret al., 2011,

    Default mode network functional and structural connectivity after traumatic brain injury

    , Brain
  • Journal article
    Bonnelle V, Leech R, Kinnunen KM, Ham T, Beckmann CF, De BX, Greenwood RJ, Sharp DJet al., 2011,

    Default mode network connectivity predicts sustained attention deficits following traumatic brain injury.

    , Journal of Neuroscience
  • Journal article
    Cannon R, Kerson C, Hampshire A, 2011,

    sLORETA and fMRI Detection of Medial Prefrontal Default Network Anomalies in Adult ADHD

    , Journal of Neurotherapy
  • Journal article
    Kempton MJ, Ettinger U, Foster R, Williams SC, Calvert GA, Hampshire A, Zelaya FO, O'Gorman RL, McMorris T, Owen AM, Smith MSet al., 2011,

    Dehydration affects brain structure and function in healthy adolescents

    , Hum Brain Mapp, Vol: 32, Pages: 71-79, ISSN: 1097-0193

    It was recently observed that dehydration causes shrinkage of brain tissue and an associated increase in ventricular volume. Negative effects of dehydration on cognitive performance have been shown in some but not all studies, and it has also been reported that an increased perceived effort may be required following dehydration. However, the effects of dehydration on brain function are unknown. We investigated this question using functional magnetic resonance imaging (fMRI) in 10 healthy adolescents (mean age = 16.8, five females). Each subject completed a thermal exercise protocol and nonthermal exercise control condition in a cross-over repeated measures design. Subjects lost more weight via perspiration in the thermal exercise versus the control condition (P < 0.0001), and lateral ventricle enlargement correlated with the reduction in body mass (r = 0.77, P = 0.01). Dehydration following the thermal exercise protocol led to a significantly stronger increase in fronto-parietal blood-oxygen-level-dependent (BOLD) response during an executive function task (Tower of London) than the control condition, whereas cerebral perfusion during rest was not affected. The increase in BOLD response after dehydration was not paralleled by a change in cognitive performance, suggesting an inefficient use of brain metabolic activity following dehydration. This pattern indicates that participants exerted a higher level of neuronal activity in order to achieve the same performance level. Given the limited availability of brain metabolic resources, these findings suggest that prolonged states of reduced water intake may adversely impact executive functions such as planning and visuo-spatial processing.

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