Search or filter publications

Filter by type:

Filter by publication type

Filter by year:

to

Results

  • Showing results for:
  • Reset all filters

Search results

  • Journal article
    Woolgar A, Hampshire A, Thompson R, Duncan Jet al., 2011,

    Adaptive coding of task-relevant information in human frontoparietal cortex

    , J Neurosci, Vol: 31, Pages: 14592-14599, ISSN: 1529-2401

    Frontoparietal cortex is thought to be essential for flexible behavior, but the mechanism for control remains elusive. Here, we demonstrate a potentially critical property of this cortex: its dynamic configuration for coding of task-critical information. Using multivoxel pattern analysis of human functional imaging data, we demonstrate an adaptive change in the patterns of activation coding task-relevant stimulus distinctions. When task demands made perceptual information more difficult to discriminate, frontoparietal regions showed increased coding of this information. Visual cortices showed the opposite result: a weaker representation of perceptual information in line with the physical change in the stimulus. On a longer timescale, a rebalancing of coding was also seen after practice, with a diminished representation of task rules as they became familiar. The results suggest a flexible neural system, exerting cognitive control in a wide range of tasks by adaptively representing the task features most challenging for successful goal-directed behavior.

  • Journal article
    Hampshire A, Thompson R, Duncan J, Owen AMet al., 2011,

    Lateral prefrontal cortex subregions make dissociable contributions during fluid reasoning

    , Cereb Cortex, Vol: 21, Pages: 1-10, ISSN: 1460-2199

    Reasoning is a key component of adaptable "executive" behavior and is known to depend on a network of frontal and parietal brain regions. However, the mechanisms by which this network supports reasoning and adaptable behavior remain poorly defined. Here, we examine the relationship between reasoning, executive control, and frontoparietal function in a series of nonverbal reasoning experiments. Our results demonstrate that, in accordance with previous studies, a network of frontal and parietal brain regions is recruited during reasoning. Our results also reveal that this network can be fractionated according to how different subregions respond when distinct reasoning demands are manipulated. While increased rule complexity modulates activity within a right lateralized network including the middle frontal gyrus and the superior parietal cortex, analogical reasoning demand-or the requirement to remap rules on to novel features-recruits the left inferior rostrolateral prefrontal cortex and the lateral occipital complex. In contrast, the posterior extent of the inferior frontal gyrus, associated with simpler executive demands, is not differentially sensitive to rule complexity or analogical demand. These findings accord well with the hypothesis that different reasoning demands are supported by different frontal and parietal subregions.

  • Conference paper
    Deligianni F, Robinson E, Sharp D, Edwards AD, Rueckert D, Alexander DCet al., 2011,

    EXPLOITING HIERARCHY IN STRUCTURAL BRAIN NETWORKS

    , 8th IEEE International Symposium on Biomedical Imaging (ISBI) - From Nano to Macro, Publisher: IEEE, Pages: 871-874, ISSN: 1945-7928
  • Journal article
    Daud NM, Ismail N, Thomas EL, Scholtz S, Durighel G, Fitzpatrick JA, Goldstone AP, Bell JD, Bech PR, Chambers E, Chhina N, Ghatei MA, Pedersen C, Frost GSet al., 2011,

    Effects of 8 weeks oligofructose supplementation on appetite and body weight in overweight and obese adults

    , PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 70, Pages: E374-E374, ISSN: 0029-6651
  • Journal article
    Scott G, Cross F, 2010,

    Reducing insulin errors Try electronic prescribing

    , BMJ-BRITISH MEDICAL JOURNAL, Vol: 341, ISSN: 1756-1833
  • Journal article
    Scott G, Cross F, 2010,

    Reducing insulin errors. Try electronic prescribing.

    , BMJ, Vol: 341
  • Journal article
    Sharp DJ, Turkheimer FE, Bose SK, Scott SK, Wise RJSet al., 2010,

    Increased Frontoparietal integration after Stroke and Cognitive Recovery

    , ANNALS OF NEUROLOGY, Vol: 68, Pages: 753-756, ISSN: 0364-5134
  • Conference paper
    Sharp D, Leech PJR, Bonnelle V, Beckmann CF, De Boissezon X, Greenwood R, Kinnunen Ket al., 2010,

    ALTERED STRUCTURAL AND FUNCTIONAL NETWORK CONNECTIVITY PREDICTS COGNITIVE FUNCTION AFTER TRAUMATIC BRAIN INJURY

    , Annual Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, Pages: E23-E23, ISSN: 0022-3050
  • Conference paper
    Goldstone AP, de Hernandez CGP, Scholtz S, Durighel G, Ashby DR, Beckmann CF, Frost GS, Bloom SR, Bell JDet al., 2010,

    Ghrelin Mimics Fasting in Preferentially Increasing Reward Responses to High-Calorie Foods

    , 28th Annual Scientific Meeting of the Obesity, Publisher: NATURE PUBLISHING GROUP, Pages: S47-S48, ISSN: 1930-7381
  • Conference paper
    Chhina N, Tan T, Ramachandran R, Goldstone AP, Palazzo F, Al-Nahhas A, Todd JF, Meeran Ket al., 2010,

    Debulking surgery prior to <SUP>177</SUP>Lutetium-DOTATATE therapy in management of metastatic bronchial carcinoid

    , 18th International Symposium on Regulatory Peptides, Publisher: ELSEVIER SCIENCE BV, Pages: 15-15, ISSN: 0167-0115

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://www.imperial.ac.uk:80/respub/WEB-INF/jsp/search-t4-html.jsp Request URI: /respub/WEB-INF/jsp/search-t4-html.jsp Query String: id=1053&limit=10&page=34&respub-action=search.html Current Millis: 1711618780915 Current Time: Thu Mar 28 09:39:40 GMT 2024