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  • Book chapter
    Gruszka A, Hampshire A, Owen AM, 2010,

    Learned Irrelevance Revisited: Pathology-Based Individual Differences, Normal Variation and Neural Correlates

    , Handbook of Individual Differences in Cognition, Editors: Gruszka, Matthews, Szymura, New York, Publisher: Springer
  • Journal article
    O'Donovan G, Thomas EL, McCarthy JP, Fitzpatrick J, Durighel G, Mehta S, Morin SX, Goldstone AP, Bell JDet al., 2009,

    Fat distribution in men of different waist girth, fitness level and exercise habit

    , INTERNATIONAL JOURNAL OF OBESITY, Vol: 33, Pages: 1356-1362, ISSN: 0307-0565
  • Conference paper
    Stutzmann F, Ghoussaini M, Couturier C, Marchand M, Vatin V, Corset L, Lecoeur C, Balkau B, Horber F, Driscoll DJ, Goldstone AP, Weill J, Michaud JL, Meyre D, Froguel Pet al., 2009,

    Loss-of-function mutations in SIM1 cause a specific form of Prader-Willi-like syndrome

    , 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Publisher: SPRINGER, Pages: S104-S104, ISSN: 0012-186X
  • Journal article
    Tauber M, Hokken-Koelega AC, Hauffa BP, Goldstone APet al., 2009,

    About the benefits of growth hormone treatment in children with Prader-Willi syndrome

    , JOURNAL OF PEDIATRICS, Vol: 154, Pages: 778-778, ISSN: 0022-3476
  • Journal article
    Piech RM, Hampshire A, Owen AM, Parkinson JAet al., 2009,

    Modulation of cognitive flexibility by hunger and desire

    , Cognition & Emotion
  • Journal article
    Goldstone AP, de Hernandez CG, Beaver JD, Muhammed K, Croese C, Bell G, Durighel G, Hughes E, Waldman AD, Frost G, Bell JDet al., 2009,

    Fasting biases brain reward systems towards high-calorie foods

    , Vol: 30, Pages: 1625-1635, ISSN: 1460-9568
  • Journal article
    Hampshire A, Thompson R, Duncan J, Owen AMet al., 2009,

    Selective tuning of the right inferior frontal gyrus during target detection

    , Cogn Affect Behav Neurosci, Vol: 9, Pages: 103-112, ISSN: 1530-7026

    In the human brain, a network of frontal and parietal regions is commonly recruited during tasks that demand the deliberate, focused control of thought and action. Previously, using a simple target detection task, we reported striking differences in the selectivity of the BOLD response in anatomically distinct subregions of this network. In particular, it was observed that the right inferior frontal gyrus (IFG) followed a tightly tuned function, selectively responding only to the current target object. Here, we examine this functional specialization further, using adapted versions of our original task. Our results demonstrate that the response of the right IFG to targets is a strong and replicable phenomenon. It occurs under increased attentional load, when targets and distractors are equally frequent, and when controlling for inhibitory processes. These findings support the hypothesis that the right IFG responds selectively to those items that are of the most relevance to the currently intended task schema.

  • Journal article
    Chamberlain SR, Hampshire A, Müller U, Rubia K, del Campo N, Craig K, Regenthal R, Suckling J, Roiser JP, Grant JE, Bullmore ET, Robbins TW, Sahakian BJet al., 2009,

    Atomoxetine Modulates Right Inferior Frontal Activation During Inhibitory Control: A Pharmacological Functional Magnetic Resonance Imaging Study

    , Biological Psychiatry, Vol: 65, Pages: 550-555, ISSN: 0006-3223

    BACKGROUND: Atomoxetine, a selective noradrenaline reuptake inhibitor (SNRI) licensed for the treatment of attention-deficit/hyperactivity disorder (ADHD), has been shown to improve response inhibition in animals, healthy volunteers, and adult patients. However, the mechanisms by which atomoxetine improves inhibitory control have yet to be determined. METHODS: The effects of atomoxetine (40 mg) were measured with a stop-signal functional magnetic resonance imaging (fMRI) paradigm in 19 healthy volunteers, in a within-subject, double-blind, placebo-controlled design. RESULTS: Atomoxetine improved inhibitory control and increased activation in the right inferior frontal gyrus when volunteers attempted to inhibit their responses (irrespective of success). Plasma levels of drug correlated significantly with right inferior frontal gyrus activation only during successful inhibition. CONCLUSIONS: These results show that atomoxetine exerts its beneficial effects on inhibitory control via modulation of right inferior frontal function, with implications for understanding and treating inhibitory dysfunction of ADHD and other disorders.

  • Journal article
    Berry E, Hampshire A, Rowe J, Hodges S, Kapur N, Watson P, Browne G, Smyth G, Wood K, Owen AMet al., 2009,

    The neural basis of effective memory therapy in a patient with limbic encephalitis

    , J Neurol Neurosurg Psychiatry, Vol: 80, Pages: 1202-1205, ISSN: 1468-330X

    BACKGROUND: An fMRI study is described in which a postencephalitic woman with amnesia used a wearable camera which takes photographs passively, without user intervention, to record and review recent autobiographical events. "SenseCam" generates hundreds of images which can subsequently be reviewed quickly or one by one. RESULTS: Memory for a significant event was improved substantially when tested after 4.5 weeks, if the patient viewed SenseCam images of the event every 2 days for 3 weeks. In contrast, after only 3.5 weeks, her memory was at chance levels for a similarly significant event which was reviewed equally often, but using a written diary. During the fMRI scan, the patient viewed images of these two events, plus images of an unrehearsed event and images from a novel "control" event that she had never experienced. There was no difference in behavioural responses or in activation when the unrehearsed and novel conditions were compared. Relative to the written-rehearsed condition, successful recognition of the images in the SenseCam-rehearsed condition was associated with activation of frontal and posterior cortical regions associated with normal episodic memory. CONCLUSION: SenseCam images may provide powerful cues that trigger the recall and consolidation of stored but inaccessible memories.

  • Book chapter
    Owen A, Hampshire A, 2009,

    The mid-ventrolateral frontal cortex and attentional control

    , Neuroimaging in Human Memory: Linking cognitive processes to neural systems., Editors: Rosler, Ranganath, Roder, Kluwe, Oxford, Publisher: OUP Oxford

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