@article{Hampshire:2012:10.1016/j.neuroimage.2011.10.072,
author = {Hampshire, A and Chaudhry, AM and Owen, AM and Roberts, AC},
doi = {10.1016/j.neuroimage.2011.10.072},
journal = {Neuroimage},
pages = {4102--4112},
title = {Dissociable roles for lateral orbitofrontal cortex and lateral prefrontal cortex during preference driven reversal learning},
url = {http://dx.doi.org/10.1016/j.neuroimage.2011.10.072},
volume = {59},
year = {2012}
}

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TY  - JOUR
AB  - One of the archetypal task manipulations known to depend on frontal-lobe function is reversal learning, where a dominant response must be overridden due to changes in the contingencies relating stimuli, responses, and environmental feedback. Previous studies have indicated that the lateral prefrontal cortex (LPFC), the lateral orbitofrontal cortex (LOFC), the anterior cingulate cortex (ACC), and the caudate nucleus (CN) all contribute to reversal learning. However, the exact contributions that they make during this cognitively complex task remain poorly defined. Here, using functional magnetic resonance imaging, we examine which of the cognitive processes that contribute to the performance of a reversal best predicts the pattern of activation within distinct sub-regions of the frontal lobes. We demonstrate that during reversal learning the LOFC is particularly sensitive to the implementation of the reversal, whereas the LPFC is recruited more generally during attentional control. By contrast, the ACC and CN respond when new searches are initiated regardless of whether the previous response is available, whilst medial orbitofrontal cortex (MOFC) activity is correlated with the positive affect of feedback. These results accord well with the hypothesis that distinct components of adaptable behaviour are supported by anatomically distinct components of the executive system.
AU  - Hampshire,A
AU  - Chaudhry,AM
AU  - Owen,AM
AU  - Roberts,AC
DO  - 10.1016/j.neuroimage.2011.10.072
EP  - 4112
PY  - 2012///
SN  - 1095-9572
SP  - 4102
TI  - Dissociable roles for lateral orbitofrontal cortex and lateral prefrontal cortex during preference driven reversal learning
T2  - Neuroimage
UR  - http://dx.doi.org/10.1016/j.neuroimage.2011.10.072
UR  - http://www.ncbi.nlm.nih.gov/pubmed/22075266
VL  - 59
ER  - 

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