@article{Chamberlain:2010:10.1001/archgenpsychiatry.2010.109,
author = {Chamberlain, SR and Hampshire, A and Menzies, L and Garyfallidis, E and Grant, JE and Odlaug, BL and Craig, K and Fineberg, N and Sahakian, BJ},
doi = {10.1001/archgenpsychiatry.2010.109},
journal = {Archives of General Psychiatry},
pages = {965--965},
title = {Reduced brain white matter integrity in trichotillomania: a diffusion tensor imaging study.},
url = {http://dx.doi.org/10.1001/archgenpsychiatry.2010.109},
volume = {67},
year = {2010}
}

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TY  - JOUR
AB  - CONTEXT: Trichotillomania is an Axis I disorder characterized by repetitive, pathological hair pulling. OBJECTIVE: To assess the integrity of white matter tracts in subjects with the disorder. DESIGN: Between-group comparison using permutation cluster analysis, with stringent correction for multiple comparisons. SETTING: Academic psychiatry department. PARTICIPANTS: Eighteen volunteers meeting DSM-IV criteria for trichotillomania and 19 healthy control subjects. MAIN OUTCOME MEASURES: Fractional anisotropy (measured using diffusion tensor imaging), trichotillomania disease severity (Massachusetts General Hospital Hairpulling Scale score), and dysphoria (Montgomery-Asberg Depression Rating Scale score). RESULTS: Subjects with trichotillomania exhibited significantly reduced fractional anisotropy in anterior cingulate, presupplementary motor area, and temporal cortices. Fractional anisotropy did not correlate significantly with trichotillomania disease severity or depressive mood scores. CONCLUSIONS: These data implicate disorganization of white matter tracts involved in motor habit generation and suppression, along with affective regulation, in the pathophysiology of trichotillomania.
AU  - Chamberlain,SR
AU  - Hampshire,A
AU  - Menzies,L
AU  - Garyfallidis,E
AU  - Grant,JE
AU  - Odlaug,BL
AU  - Craig,K
AU  - Fineberg,N
AU  - Sahakian,BJ
DO  - 10.1001/archgenpsychiatry.2010.109
EP  - 965
PY  - 2010///
SN  - 0003-990X
SP  - 965
TI  - Reduced brain white matter integrity in trichotillomania: a diffusion tensor imaging study.
T2  - Archives of General Psychiatry
UR  - http://dx.doi.org/10.1001/archgenpsychiatry.2010.109
UR  - http://www.ncbi.nlm.nih.gov/pubmed/20819990
VL  - 67
ER  - 

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