@article{Chamberlain:2008:10.1126/science.1154433,
author = {Chamberlain, SR and Menzies, L and Hampshire, A and Suckling, J and Fineberg, NA and del, Campo N and Aitken, M and Craig, K and Owen, AM and Bullmore, ET and Robbins, TW and Sahakian, BJ},
doi = {10.1126/science.1154433},
journal = {Science},
pages = {421--422},
title = {Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives},
url = {http://dx.doi.org/10.1126/science.1154433},
volume = {321},
year = {2008}
}

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TY  - JOUR
AB  - Obsessive-compulsive disorder (OCD) is characterized by repetitive thoughts and behaviors associated with underlying dysregulation of frontostriatal circuitry. Central to neurobiological models of OCD is the orbitofrontal cortex, a neural region that facilitates behavioral flexibility after negative feedback (reversal learning). We identified abnormally reduced activation of several cortical regions, including the lateral orbitofrontal cortex, during reversal learning in OCD patients and their clinically unaffected close relatives, supporting the existence of an underlying previously undiscovered endophenotype for this disorder.
AU  - Chamberlain,SR
AU  - Menzies,L
AU  - Hampshire,A
AU  - Suckling,J
AU  - Fineberg,NA
AU  - del,Campo N
AU  - Aitken,M
AU  - Craig,K
AU  - Owen,AM
AU  - Bullmore,ET
AU  - Robbins,TW
AU  - Sahakian,BJ
DO  - 10.1126/science.1154433
EP  - 422
PY  - 2008///
SN  - 1095-9203
SP  - 421
TI  - Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives
T2  - Science
UR  - http://dx.doi.org/10.1126/science.1154433
UR  - http://www.ncbi.nlm.nih.gov/pubmed/18635808
VL  - 321
ER  - 

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