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Journal articleGuo WH, Tian L, Chan KL, et al., 2001,
Role of CD4+ and CD8+ T cells in early and late acute rejection of small bowel allograft.
, J Pediatr Surg, Vol: 36, Pages: 352-356, ISSN: 0022-3468BACKGROUND/PURPOSE: Results of small bowel transplantation remain unsatisfactory because of severe immune rejection. The current study aims to elucidate the role of activation of CD4+ and CD8+ T cells in early and late acute rejection of small bowel allograft and, hence, provide the immunologic basis for developing new therapeutic strategies. METHODS: We used an MHC fully mismatched (DA to Lewis) heterotopic rat small bowel transplant model and a unique FK506-based immunosuppressive regimen, which suppresses early acute rejection but does not prevent late acute rejection. Flow cytometric analysis was used to quantitate the number of activated CD4+ and CD8+ T cells in graft and host mesenteric lymph nodes. RESULTS: The survival (mean +/- SD) of intestinal allograft was significantly prolonged, from 6.6 +/- 0.84 days for the untreated group to 40.7 +/- 14.1 days for the FK506-treated group. Activation of CD4+ cells was suppressed significantly in the FK506-treated group on postoperative day 7 compared with the untreated group (29.4% +/- 3.55% v 52.83% +/- 11.9%; P <.01). Activation of CD8+ cells was similarly suppressed (31.5 +/- 10.34% v 48.53 +/- 14.34%; P <.05). Interestingly, at late acute rejection, activated CD4+ and CD8+ T cells remained at almost the same low levels as those on postoperative day 7 in the FK506-treated group. The spleen to body weight ratio was significantly increased in the untreated group (0.53 +/- 0.07), and slightly increased in the FK treated group (0.27 +/- 0.07, on postoperative day 7; 0.24 +/- 0.07 at late acute rejection) compared with the syngeneic group (0.18 +/- 0.02). CONCLUSION: The activation of CD4+ and CD8+ T cells was suppressed effectively by early potent immunosuppressive treatment resulting in prolonged survival of intestinal allograft. At late acute rejection, the CD4+ and CD8+ T cells remained at low-level activation status, in contrast to the surge of CD4+ and CD8+ activation during early acute rejection. This sugg
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Journal articleTodo T, Martuza RL, Dallman MJ, et al., 2001,
<i>In situ</i> expression of soluble B7-1 in the context of oncolytic herpes simplex virus induces potent antitumor immunity
, CANCER RESEARCH, Vol: 61, Pages: 153-161, ISSN: 0008-5472- Author Web Link
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- Citations: 77
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Journal articleLamb J, Dallman MJ, Hoyne GF, 2001,
Regulatory T cells: A role for notch signalling
, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 31, Pages: 165-165, ISSN: 0954-7894 -
Journal articleBugeon L, Hargreaves REG, Crompton T, et al., 2001,
Selective silencing of full-length CD80 but not IgV-CD80 leads to impaired clonal deletion of self-reactive T cells and altered regulation of immune responses
, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 31, Pages: 118-127, ISSN: 0014-2980- Author Web Link
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- Citations: 6
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Conference paperGuo WH, Tian L, Yuen ZW, et al., 2000,
Recipient FK506 pretreatment regimens in rat small bowel transplantation: Allograft survival, function, and systemic infection
, 33rd Annual Meeting of the Pacific-Association-of-Pediatric-Surgeons, Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: 1600-1605, ISSN: 0022-3468- Author Web Link
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- Citations: 5
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Journal articleBugeon L, Dallman MJ, 2000,
Costimulation of T cells
, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 162, Pages: S164-S168, ISSN: 1073-449X- Author Web Link
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- Citations: 55
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Journal articleQuattrocchi E, Dallman MJ, Feldmann M, 2000,
Adenovirus-mediated gene trans fer of CTLA-4Ig fusion protein in the suppression of experimental autoimmune arthritis
, ARTHRITIS AND RHEUMATISM, Vol: 43, Pages: 1688-1697, ISSN: 0004-3591- Author Web Link
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- Citations: 54
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Journal articleHoyne GF, Dallman MJ, Lamb JR, 2000,
T-cell regulation of peripheral tolerance and immunity: the potential role for Notch signalling
, IMMUNOLOGY, Vol: 100, Pages: 281-288, ISSN: 0019-2805- Author Web Link
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- Citations: 32
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Journal articleBugeon L, Syed N, Dallman MJ, 2000,
A fast and efficient method for transiently transfecting ES cells: application to the development of systems for conditional gene expression
, TRANSGENIC RESEARCH, Vol: 9, Pages: 229-232, ISSN: 0962-8819- Author Web Link
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- Citations: 10
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Journal articleDeonarain R, Alcamí A, Alexiou M, et al., 2000,
Impaired antiviral response and alpha/beta interferon induction in mice lacking beta interferon
, JOURNAL OF VIROLOGY, Vol: 74, Pages: 3404-3409, ISSN: 0022-538X- Author Web Link
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- Citations: 137
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Journal articleHoyne GF, Le Roux I, Corsin-Jimenez M, et al., 2000,
<i>Serrate1</i>-induced <i>Notch</i> signalling regulates the decision between immunity and tolerance made by peripheral CD4<SUP>+</SUP> T cells
, INTERNATIONAL IMMUNOLOGY, Vol: 12, Pages: 177-185, ISSN: 0953-8178- Author Web Link
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- Citations: 169
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Journal articleHirschberg S, Layton GT, Harris SJ, et al., 1999,
CD4<SUP>+</SUP> T cells induced by virus-like particles expressing a major T cell epitope downregulate IL-5 production in an ongoing immune response to Der p 1 independently of IFN-γ production
, INTERNATIONAL IMMUNOLOGY, Vol: 11, Pages: 1927-1933, ISSN: 0953-8178- Author Web Link
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- Citations: 8
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Journal articleHirschberg S, Layton GT, Harris SJ, et al., 1999,
CD4(+) T cells induced by virus-like particles expressing a major T cell epitope down-regulate IL-5 production in an ongoing immune response to Der p 1 independently of IFN-gamma production.
, Int Immunol, Vol: 11, Pages: 1927-1934, ISSN: 0953-8178It has been previously demonstrated that hybrid Ty virus-like particles (VLP) prime effective CD8(+) and CD4(+) T cell responses. In this study, we investigated the effect of treating mice with Ty VLP carrying the immunodominant epitope of Der p 1 after sensitizing them to the group 1 allergen of the house dust mite Dermatophagoides pteronyssinus (Der p 1), under conditions that induce T(h)2 immunity. We show that i.p. treatment with the hybrid VLP abrogated allergen-specific IL-5 production and reduced allergen-specific cell proliferation. This suppression of the response was mediated by CD4(+) T cells and was not accompanied by an increase in IFN-gamma production.
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Journal articleHoyne GF, Dallman MJ, Lamb JR, 1999,
Linked suppression in peripheral T cell tolerance to the house bust mite derived allergen Der p 1
, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, Vol: 118, Pages: 122-124, ISSN: 1018-2438- Author Web Link
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- Citations: 27
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Journal articleCroxford JL, O'Neill JK, Ali RR, et al., 1998,
Local gene therapy with CTLA4-immunoglobulin fusion protein in experimental allergic encephalomyelitis
, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 28, Pages: 3904-3916, ISSN: 0014-2980- Author Web Link
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- Citations: 42
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Journal articleYoung NT, Rust NA, Dallman MJ, et al., 1998,
Independent contributions of HLA epitopes and killer inhibitory receptor expression to the functional alloreactive specificity of natural killer cells
, HUMAN IMMUNOLOGY, Vol: 59, Pages: 700-712, ISSN: 0198-8859- Author Web Link
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- Citations: 13
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Journal articleDallman MJ, 1998,
Polymerase chain reaction methods in immunology
, TRANSPLANTATION PROCEEDINGS, Vol: 30, Pages: 2367-2369, ISSN: 0041-1345- Author Web Link
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- Citations: 2
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Journal articleYoung NT, Roelen DL, Dallman MJ, et al., 1998,
HLA-DRB1 amino acid disparity is the major stimulus of interleukin-2 production by alloreactive helper T-lymphocytes
, IMMUNOGENETICS, Vol: 47, Pages: 310-317, ISSN: 0093-7711- Author Web Link
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- Citations: 8
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Journal articlePorter ACG, Dallman MJ, 1997,
Gene targeting - Techniques and applications to transplantation
, TRANSPLANTATION, Vol: 64, Pages: 1227-1235, ISSN: 0041-1337 -
Journal articleOzasa T, Newton MR, Dallman MJ, et al., 1997,
Cytokine gene expression in pancreatic islet grafts in the rat
, TRANSPLANTATION, Vol: 64, Pages: 1152-1159, ISSN: 0041-1337- Author Web Link
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- Citations: 29
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Journal articleMontgomery RA, Dallman MJ, 1997,
Semi-quantitative polymerase chain reaction analysis of cytokine and cytokine receptor gene expression during thymic ontogeny
, CYTOKINE, Vol: 9, Pages: 717-726, ISSN: 1043-4666- Author Web Link
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- Citations: 18
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Journal articleOral HB, Larkin DFP, Fehervari Z, et al., 1997,
Ex vivo adenovirus-mediated gene transfer and immunomodulatory protein production in human cornea
, GENE THERAPY, Vol: 4, Pages: 639-647, ISSN: 0969-7128- Author Web Link
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- Citations: 79
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Journal articleToogood GJ, Rankin AM, Tam PKH, et al., 1997,
The immune response following small bowel transplantation .2. A very early cytokine response in the gut-associated lymphoid tissue
, TRANSPLANTATION, Vol: 63, Pages: 1118-1123, ISSN: 0041-1337- Author Web Link
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- Citations: 13
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Journal articleYoung NT, Roelen DL, Iggo N, et al., 1997,
Effect of one-HLA-haplotype-matched and HLA-mismatched blood transfusions on recipient T lymphocyte allorepertoires
, TRANSPLANTATION, Vol: 63, Pages: 1160-1165, ISSN: 0041-1337- Author Web Link
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- Citations: 15
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Journal articleWilletts IE, Tam PKH, Morris PJ, et al., 1997,
Treatment with an HLA-peptide and cyclosporine A prolongs rat small bowel allograft survival
, JOURNAL OF PEDIATRIC SURGERY, Vol: 32, Pages: 469-472, ISSN: 0022-3468- Author Web Link
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- Citations: 6
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Journal articleMcLean AG, Hughes D, Welsh KI, et al., 1997,
Patterns of graft infiltration and cytokine gene expression during the first 10 days of kidney transplantation
, TRANSPLANTATION, Vol: 63, Pages: 374-380, ISSN: 0041-1337- Author Web Link
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- Citations: 57
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Conference paperYoung NT, Roelen DL, Bunce M, et al., 1997,
Alloreactive helper T-lymphocyte precursor frequencies correlate with HLA-DRB1 antigen amino acid residue mismatches
, 12th International Histocompatibility Conference - HLA, Publisher: EDITIONS EDK, Pages: 501-503 -
Journal articleDallman MJ, 1996,
Molecular biology of the allograft response
, TRANSPLANTATION PROCEEDINGS, Vol: 28, Pages: 2-6, ISSN: 0041-1345- Author Web Link
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- Citations: 6
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Journal articleToogood GJ, Rankin AM, Tam PKH, et al., 1996,
The immune response following small bowel transplantation .1. An unusual pattern of cytokine expression
, TRANSPLANTATION, Vol: 62, Pages: 851-855, ISSN: 0041-1337- Author Web Link
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- Citations: 20
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Journal articleYoung NT, Roelen DL, Wood KJ, et al., 1996,
Primary alloreactive cytotoxic T-lymphocytes are not commonly restricted by self-HLA Class I antigens
, HUMAN IMMUNOLOGY, Vol: 50, Pages: 38-46, ISSN: 0198-8859- Author Web Link
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- Citations: 5
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