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Journal articleYoung NT, Roelen DL, Dallman MJ, et al., 1996,
Enumeration of human alloreactive helper T lymphocyte precursor frequencies by limiting dilution analysis of interleukin-2 production
, JOURNAL OF IMMUNOLOGICAL METHODS, Vol: 195, Pages: 33-41, ISSN: 0022-1759- Author Web Link
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- Citations: 10
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Journal articleYoung NT, Roelen DL, Bunce M, et al., 1996,
Alloreactive helper T-lymphocyte precursor frequencies correlate with HLA-DR antigen amino acid residue mismatches
, HUMAN IMMUNOLOGY, Vol: 47, Pages: O877-O877, ISSN: 0198-8859 -
Journal articleJOSIEN R, PANNETIER C, DOUILLARD P, et al., 1995,
GRAFT-INFILTRATING T-HELPER CELLS, CD45RC PHENOTYPE, AND TH1/TH2-RELATED CYTOKINES IN DONOR-SPECIFIC TRANSFUSION-INDUCED TOLERANCE IN ADULT-RATS
, TRANSPLANTATION, Vol: 60, Pages: 1131-1139, ISSN: 0041-1337- Author Web Link
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- Citations: 78
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Journal articleBall ST, Dallman MJ, 1995,
Transplantation immunology.
, Curr Opin Nephrol Hypertens, Vol: 4, Pages: 465-471, ISSN: 1062-4821The success of transplantation is such that it is now the treatment of choice for many of those requiring renal replacement therapy. The use of other solid organs, including liver, pancreas, heart and lung, continues to progress. This article reviews some recent advances in our understanding of the immunological response to alloantigen and xenoantigen.
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Journal articleDALLMAN MJ, 1995,
CYTOKINES AND TRANSPLANTATION - TH1/TH2 REGULATION OF THE IMMUNE-RESPONSE TO SOLID-ORGAN TRANSPLANTS IN THE ADULT
, CURRENT OPINION IN IMMUNOLOGY, Vol: 7, Pages: 632-638, ISSN: 0952-7915- Author Web Link
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- Citations: 131
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Journal articleTACKE M, CLARK GJ, DALLMAN MJ, et al., 1995,
CELLULAR-DISTRIBUTION AND COSTIMULATORY FUNCTION OF RAT CD28 - REGULATED EXPRESSION DURING THYMOCYTE MATURATION AND INDUCTION OF CYCLOSPORINE-A SENSITIVITY OF COSTIMULATED T-CELL RESPONSES BY PHORBOL ESTER
, JOURNAL OF IMMUNOLOGY, Vol: 154, Pages: 5121-5127, ISSN: 0022-1767- Author Web Link
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- Citations: 46
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Journal articleHIGGINS RM, DALLMAN MJ, 1995,
ENHANCEMENT AND INHIBITION OF CELLULAR RESPONSIVENESS MEDIATED BY THE ANTILEUKOCYTE MONOCLONAL-ANTIBODY NDS-71
, IMMUNOLOGY LETTERS, Vol: 46, Pages: 37-42, ISSN: 0165-2478 -
Journal articleFARGES O, 1995,
Spontaneous acceptance of rat liver allografts is associated with an early downregulation of intragraft interleukin-4 messenger RNA expression*1, *2
, Hepatology, Vol: 21, Pages: 767-775, ISSN: 0270-9139 -
Journal articleFARGES O, MORRIS PJ, DALLMAN MJ, 1995,
SPONTANEOUS ACCEPTANCE OF RAT-LIVER ALLOGRAFTS IS ASSOCIATED WITH AN EARLY DOWN-REGULATION OF INTRAGRAFT INTERLEUKIN-4 MESSENGER-RNA EXPRESSION
, HEPATOLOGY, Vol: 21, Pages: 767-775, ISSN: 0270-9139- Author Web Link
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- Citations: 43
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Journal articleABBS IC, PRATT JR, DALLMAN MJ, et al., 1994,
DYNAMICS OF THE EXPRESSION OF THE INTERLEUKIN-2 (IL-2) RECEPTOR IN RAT RENAL-ALLOGRAFTS ANALYZED BY IMMUNOHISTOLOGY, AUTORADIOGRAPHY, AND NUCLEAR IMAGING USING RADIOIODINATED IL-2 PROBES
, TRANSPLANTATION, Vol: 58, Pages: 1284-1287, ISSN: 0041-1337- Author Web Link
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- Citations: 2
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Journal articleGORDON AC, DALLMAN MJ, MORRIS PJ, 1994,
VASCULAR ANASTOMOTIC TECHNIQUES FOR EXPERIMENTAL INTESTINAL TRANSPLANTATION
, TRANSPLANT INTERNATIONAL, Vol: 7, Pages: 368-371, ISSN: 0934-0874- Author Web Link
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- Citations: 4
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Journal articleCUTURI MC, JOSIEN R, CANTAROVICH D, et al., 1994,
DECREASED ANTIDONOR MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I AND INCREASED CLASS-II ALLOANTIBODY RESPONSE IN ALLOGRAFT TOLERANCE IN ADULT-RATS
, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 24, Pages: 1627-1631, ISSN: 0014-2980- Author Web Link
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- Citations: 41
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Journal articlePARKER KE, BUGEON L, CUTURI MC, et al., 1994,
CLONING OF CDNA CODING FOR THE RAT MU-HEAVY-CHAIN CONSTANT-REGION - DIFFERENCES BETWEEN RAT ALLOTYPES
, IMMUNOGENETICS, Vol: 39, Pages: 159-159, ISSN: 0093-7711- Author Web Link
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- Citations: 5
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Journal articleFARGES O, MORRIS PJ, DALLMAN MJ, 1994,
SPONTANEOUS ACCEPTANCE OF LIVER ALLOGRAFTS IN THE RAT - ANALYSIS OF THE IMMUNE-RESPONSE
, TRANSPLANTATION, Vol: 57, Pages: 171-177, ISSN: 0041-1337- Author Web Link
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- Citations: 48
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Journal articleParker KE, Bugeon L, Cuturi MC, et al., 1994,
Cloning of cDNA coding for the rat mu heavy chain constant region: differences between rat allotypes.
, Immunogenetics, Vol: 39, ISSN: 0093-7711 -
Journal articleDALLMAN MJ, 1993,
CYTOKINES AS MEDIATORS OF ORGAN GRAFT-REJECTION AND TOLERANCE
, CURRENT OPINION IN IMMUNOLOGY, Vol: 5, Pages: 788-793, ISSN: 0952-7915- Author Web Link
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- Citations: 79
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Journal articleBUGEON L, CUTURI MC, PAINEAU J, et al., 1993,
SIMILAR LEVELS OF GRANZYME-A AND PERFORIN MESSENGER-RNA EXPRESSION IN REJECTED AND TOLERATED HEART ALLOGRAFTS IN DONOR-SPECIFIC TOLERANCE IN RATS
, TRANSPLANTATION, Vol: 56, Pages: 405-408, ISSN: 0041-1337- Author Web Link
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- Citations: 15
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Journal articleDALLMAN MJ, WOOD KJ, HAMANO K, et al., 1993,
CYTOKINES AND PERIPHERAL TOLERANCE TO ALLOANTIGEN
, IMMUNOLOGICAL REVIEWS, Vol: 133, Pages: 5-18, ISSN: 0105-2896- Author Web Link
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- Citations: 61
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Journal articleWOOD MJA, SLOAN DJ, DALLMAN MJ, et al., 1993,
SPECIFIC TOLERANCE TO NEURAL ALLOGRAFTS INDUCED WITH AN ANTIBODY TO THE INTERLEUKIN-2 RECEPTOR
, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 177, Pages: 597-603, ISSN: 0022-1007- Author Web Link
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- Citations: 29
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Journal articleBUGEON L, CUTURI MC, PAINEAU J, et al., 1993,
DECREASED IFN-GAMMA AND IL-2 MESSENGER-RNA EXPRESSION IN PERIPHERAL TOLERANCE TO HEART ALLOGRAFTS WITH CONSERVED GRANZYME-A, PERFORIN, AND MHC ANTIGENS MESSENGER-RNA EXPRESSION
, TRANSPLANTATION PROCEEDINGS, Vol: 25, Pages: 314-316, ISSN: 0041-1345- Author Web Link
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- Citations: 7
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Journal articleMORRIS PJ, DALLMAN MJ, WOOD KJ, 1993,
ANERGY IN ALLOGENEIC TRANSPLANTATION
, TRANSPLANTATION PROCEEDINGS, Vol: 25, Pages: 281-283, ISSN: 0041-1345- Author Web Link
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- Citations: 12
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Journal articleAbbs IC, Pratt JR, Dallman MJ, et al., 1993,
Analysis of activated T cell infiltrates in rat renal allografts by gamma camera imaging after injection of 123iodine-interleukin 2.
, Transpl Immunol, Vol: 1, Pages: 45-51, ISSN: 0966-3274Activated T cells bearing receptors for interleukin 2 (IL-2) play an important role in immunity and in immunopathological processes such as allograft rejection. In order to investigate the presence of activated T cells in lymphocytic infiltrates in transplanted kidneys, we investigated the uptake and retention of radioactivity after an intravenous injection of radioiodinated IL-2 in experimentally transplanted rats. IL-2 was enzyme radiolabelled with 123iodine using a glucose oxidase/lactoperoxidase method and shown to retain specific binding on an IL-2 receptor positive cell line, C58E6. To examine the kinetics of 123iodine-interleukin 2 (123I-IL-2) uptake in vivo, animals that had been transplanted five days previously with allogeneic or syngeneic grafts were injected with 123I-IL-2 and then imaged using an external gamma camera. Radioactivity was measured at time points up to 240 min after intravenous injection of 123I-IL-2. Four groups of animals were examined: allogeneic grafts (n = 7); syngeneic grafts (n = 6); ischaemic native kidneys (n = 5) all following injection with 123I-IL-2; and allogeneic transplants (n = 5) after injection of 123I-lactalbumin, an irrelevant molecule of similar molecular weight to IL-2. The peak radioactivity after injection was measured and the amount of radioactivity retained in the graft at increasing time intervals after injection was expressed as a function of initial peak radioactivity. At four hours after injection of 123I-IL-2, mean retention of activity by rejecting grafts was 77(+/- 2.68)% of peak activity, compared to 45(+/- 6.38)% in syngeneic controls (p < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
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Journal articleBAIGRIE RJ, LAMONT PM, KWIATKOWSKI D, et al., 1992,
SYSTEMIC CYTOKINE RESPONSE AFTER MAJOR SURGERY
, BRITISH JOURNAL OF SURGERY, Vol: 79, Pages: 757-760, ISSN: 0007-1323- Author Web Link
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- Citations: 499
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Journal articleBUGEON L, CUTURI MC, HALLET MM, et al., 1992,
PERIPHERAL TOLERANCE OF AN ALLOGRAFT IN ADULT-RATS - CHARACTERIZATION BY LOW INTERLEUKIN-2 AND INTERFERON-GAMMA MESSENGER-RNA LEVELS AND BY STRONG ACCUMULATION OF MAJOR HISTOCOMPATIBILITY COMPLEX TRANSCRIPTS IN THE GRAFT
, TRANSPLANTATION, Vol: 54, Pages: 219-225, ISSN: 0041-1337- Author Web Link
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- Citations: 115
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Journal articleWOOD MJA, SLOAN DJ, DALLMAN MJ, et al., 1992,
A MONOCLONAL-ANTIBODY TO THE INTERLEUKIN-2 RECEPTOR ENHANCES THE SURVIVAL OF NEURAL ALLOGRAFTS - A TIME-COURSE STUDY
, NEUROSCIENCE, Vol: 49, Pages: 409-418, ISSN: 0306-4522- Author Web Link
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- Citations: 26
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Journal articleBLANCHO G, BUZELIN F, DANTAL J, et al., 1992,
EVIDENCE THAT EARLY ACUTE-RENAL-FAILURE MAY BE MEDIATED BY CD3-CD16+ CELLS IN A KIDNEY GRAFT RECIPIENT WITH LARGE GRANULAR LYMPHOCYTE-PROLIFERATION
, TRANSPLANTATION, Vol: 53, Pages: 1242-1247, ISSN: 0041-1337- Author Web Link
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- Citations: 13
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Journal articleDALLMAN MJ, ROAKE J, HUGHES D, et al., 1992,
SEQUENTIAL-ANALYSIS OF IL-2 GENE-TRANSCRIPTION IN RENAL-TRANSPLANTS
, TRANSPLANTATION, Vol: 53, Pages: 683-685, ISSN: 0041-1337- Author Web Link
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- Citations: 74
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Journal articleCLARK GJ, DALLMAN MJ, 1992,
IDENTIFICATION OF A CDNA-ENCODING THE RAT CD28 HOMOLOG
, IMMUNOGENETICS, Vol: 35, Pages: 54-57, ISSN: 0093-7711- Author Web Link
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- Citations: 21
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Journal articleGORDON AC, DALLMAN MJ, MORRIS PJ, 1992,
CELLULAR INFILTRATION OF SMALL-BOWEL ALLOGRAFTS
, GUT, Vol: 33, Pages: S7-S7, ISSN: 0017-5749 -
Journal articleMORRIS PJ, WOOD KJ, DALLMAN MJ, 1991,
ANTIGEN-INDUCED TOLERANCE TO ORGAN ALLOGRAFTS
, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES, Vol: 636, Pages: 295-305- Author Web Link
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- Citations: 12
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