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• CONFERENCE PAPER
  Le Friec G, Bugeon L, Dallman M, Kemper Cet al., 2010,

  CD46: Just a Notch up your common complement regulator

  , 23rd International National Complement Workshop, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 2229-2229, ISSN: 0161-5890
  • Author Web Link
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  • Citations: 3
• CONFERENCE PAPER
  Le Friec G, Bugeon L, Dallman M, Kemper Cet al., 2010,

  CD46: just a Notch up your common complement regulator

  , Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 174-174, ISSN: 0019-2805
  • Author Web Link
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• JOURNAL ARTICLE
  Saric J, Li JV, Swann JR, Utzinger J, Calvert G, Nicholson JK, Dirnhofer S, Dallman MJ, Bictash M, Holmes Eet al., 2010,

  Integrated Cytokine and Metabolic Analysis of Pathological Responses to Parasite Exposure in Rodents

  , JOURNAL OF PROTEOME RESEARCH, Vol: 9, Pages: 2255-2264, ISSN: 1535-3893
  • Author Web Link
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  • Citations: 21
• JOURNAL ARTICLE
  Turro E, Lewin A, Rose A, Dallman MJ, Richardson Set al., 2010,

  MMBGX: a method for estimating expression at the isoform level and detecting differential splicing using whole-transcript Affymetrix arrays

  , NUCLEIC ACIDS RESEARCH, Vol: 38, ISSN: 0305-1048
  • Author Web Link
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  • Citations: 15
• JOURNAL ARTICLE
  Mollet G, Ratelade J, Boyer O, Muda AO, Morisset L, Lavin TA, Kitzis D, Dallman MJ, Bugeon L, Hubner N, Gubler M-C, Antignac C, Esquivel ELet al., 2009,

  Podocin Inactivation in Mature Kidneys Causes Focal Segmental Glomerulosclerosis and Nephrotic Syndrome

  , JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol: 20, Pages: 2181-2189, ISSN: 1046-6673
  • Author Web Link
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  • Citations: 42
• JOURNAL ARTICLE
  Bugeon L, Gardner LM, Rose A, Gentle M, Dallman MJet al., 2008,

  Cutting Edge: Notch Signaling Induces a Distinct Cytokine Profile in Dendritic Cells That Supports T Cell-Mediated Regulation and IL-2-Dependent IL-17 Production

  , JOURNAL OF IMMUNOLOGY, Vol: 181, Pages: 8189-8193, ISSN: 0022-1767
  • Cite
  • Citations: 27
• JOURNAL ARTICLE
  Chen Y, Li X, Tian L, Lui VCH, Dallman MJ, Lamb JR, Tam PKHet al., 2007,

  Inhibition of sonic hedgehog signaling reduces chronic rejection and prolongs allograft survival in a rat orthotopic small bowel transplantation model

  , TRANSPLANTATION, Vol: 83, Pages: 1351-1357, ISSN: 0041-1337
  • Cite
  • Citations: 8
• JOURNAL ARTICLE
  Chen Y, Liu Y, Yuan Z, Tian L, Dallman MJ, Thompson PW, Tam PKH, Lamb JRet al., 2007,

  Rosiglitazone suppresses cyclosporin-induced chronic transplant dysfunction and prolongs survival of rat cardiac allografts

  , TRANSPLANTATION, Vol: 83, Pages: 1602-1610, ISSN: 0041-1337
  • Author Web Link
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  • Citations: 7
• JOURNAL ARTICLE
  Bugeon L, Wong KK, Rankin AM, Hargreaves REG, Dallman MJet al., 2006,

  A negative regulatory role in mouse cardiac transplantation for a splice variant of CD80

  , TRANSPLANTATION, Vol: 82, Pages: 1334-1341, ISSN: 0041-1337
  • Author Web Link
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  • Citations: 2
• JOURNAL ARTICLE
  Chan VSF, Chau S-Y, Tian L, Chen Y, Kwong SKY, Quackenbush J, Dallman M, Lamb J, Tam PKHet al., 2006,

  Sonic hedgehog promotes CD4(+) T lymphocyte proliferation and modulates the expression of a subset of CD28-targeted genes

  , INTERNATIONAL IMMUNOLOGY, Vol: 18, Pages: 1627-1636, ISSN: 0953-8178
  • Author Web Link
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  • Citations: 9
• JOURNAL ARTICLE
  Scorey N, Fraser SP, Patel P, Pridgeon C, Dallman MJ, Djamgoz MBAet al., 2006,

  Notch signalling and voltage-gated Na+ channel activity in human prostate cancer cells: independent modulation of in vitro motility

  , PROSTATE CANCER AND PROSTATIC DISEASES, Vol: 9, Pages: 399-406, ISSN: 1365-7852
  • Author Web Link
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  • Citations: 33
• JOURNAL ARTICLE
  Tolmachova T, Anders R, Abrink M, Bugeon L, Dallman MJ, Futter CE, Ramalho JS, Tonagel F, Tanimoto N, Seeliger MW, Huxley C, Seabra MCet al., 2006,

  Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia

  , JOURNAL OF CLINICAL INVESTIGATION, Vol: 116, Pages: 386-394, ISSN: 0021-9738
  • Author Web Link
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  • Citations: 61
• JOURNAL ARTICLE
  Wagner KD, Wagner N, Guo JK, Eiger M, Dallman MJ, Bugeon L, Schedl Aet al., 2006,

  An inducible mouse model for PAX2-dependent glomerular disease: Insights into a complex pathogenesis

  , CURRENT BIOLOGY, Vol: 16, Pages: 793-800, ISSN: 0960-9822
  • Author Web Link
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  • Citations: 27
• JOURNAL ARTICLE
  Xystrakis E, Kusumakar S, Boswell S, Peek E, Urry Z, Richards DF, Adikibi T, Pridgeon C, Dallman M, Loke TK, Robinson DS, Barrat FJ, O'Garra A, Lavender P, Lee TH, Corrigan C, Hawrylowicz CMet al., 2006,

  Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients

  , JOURNAL OF CLINICAL INVESTIGATION, Vol: 116, Pages: 146-155, ISSN: 0021-9738
  • Author Web Link
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  • Citations: 364
• JOURNAL ARTICLE
  Carlin LM, Yanagi K, Verhoef A, Hoen ENMN, Yates J, Gardner L, Lamb J, Lombardi G, Dallman MJ, Davis DMet al., 2005,

  Secretion of IFN-gamma and not IL-2 by anergic human T cells correlates with assembly of an immature immune synapse

  , BLOOD, Vol: 106, Pages: 3874-3879, ISSN: 0006-4971
  • Cite
  • Citations: 16
• JOURNAL ARTICLE
  Dallman MJ, Smith E, Benson RA, Lamb JRet al., 2005,

  Notch: Control of lymphocyte differentiation in the periphery

  , CURRENT OPINION IN IMMUNOLOGY, Vol: 17, Pages: 259-266, ISSN: 0952-7915
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  • Citations: 37
• CONFERENCE PAPER
  Notley CA, Robinson DS, Dallman MJ, 2005,

  The indirect pathway of allorecognition is actively regulated by CD4+CD25+ regulatory T cells.

  , 6th American Transplant Congress, Publisher: BLACKWELL PUBLISHING, Pages: 498-499, ISSN: 1600-6135
  • Author Web Link
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• JOURNAL ARTICLE
  Ling EM, Smith T, Nguyen XD, Pridgeon C, Dallman M, Arbery J, Carr VAet al., 2004,

  Relation of CD4+CD25+ regulatory T cell suppression of allergen-driven T cell activation is related to atopic status and expression of allergic disease

  , Lancet, Vol: 363, Pages: 608-615
  • Cite
• JOURNAL ARTICLE
  Ling EM, Smith T, Nguyen XD, Pridgeon C, Dallman M, Arbery J, Carr VA, Robinson DSet al., 2004,

  Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease

  , LANCET, Vol: 363, Pages: 608-615, ISSN: 0140-6736
  • Author Web Link
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  • Citations: 525
• JOURNAL ARTICLE
  Bugeon L, Danou A, Carpentier D, Langridge P, Syed N, Dallman MJet al., 2003,

  Inducible gene silencing in podocytes: A new tool for studying glomerular function

  , JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol: 14, Pages: 786-791, ISSN: 1046-6673
  • Author Web Link
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  • Citations: 21
• JOURNAL ARTICLE
  Dallman MJ, Champion B, Lamb JR, 2003,

  Notch signalling in the peripheral immune system.

  , Novartis Found Symp, Vol: 252, Pages: 268-276, ISSN: 1528-2511

  Peripheral T cell tolerance is critical in the regulation of immune responses to self antigens, and has implications in the control of autoimmunity, allergic responses and transplant rejection. Here we discuss recent and unpublished data demonstrating that ligation of the cell surface receptor Notch on T cells inhibits immune responses and results in the generation of a regulatory T cell population. Using animal models, we show that prior exposure to antigen can inhibit the response to challenge in an antigen-specific fashion. This inhibition is accompanied by the generation of cells with apparent regulatory capacity and we further show that exposure of T cells to Notch and T cell receptor signals together enhances interleukin 10 production, at least in cell culture systems. We discuss how Notch signalling may integrate with other signals to induce tolerance.

  • Abstract
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• JOURNAL ARTICLE
  Lui VCH, Tam PKH, Leung MYK, Lau JYB, Chan JKY, Chan VSF, Dallman M, Cheah KSEet al., 2003,

  Mammary gland-specific secretion of biologically active immunosuppressive agent cytotoxic-T-lymphocyte antigen 4 human immunoglobulin fusion protein (CTLA4Ig) in milk by transgenesis

  , JOURNAL OF IMMUNOLOGICAL METHODS, Vol: 277, Pages: 171-183, ISSN: 0022-1759
  • Author Web Link
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  • Citations: 8
• JOURNAL ARTICLE
  Mckenzie GJ, Young LL, Briend E, Lamb JR, Dallman MJ, Champion BRet al., 2003,

  Notch signalling in the regulation of peripheral T-cell function

  , SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, Vol: 14, Pages: 127-134, ISSN: 1084-9521
  • Author Web Link
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  • Citations: 14
• JOURNAL ARTICLE
  Waddington SN, Buckley SMK, Nivsarkar M, Jezzard S, Schneider H, Dahse T, Kemball-Cook G, Miah M, Tucker N, Dallman MJ, Themis M, Coutelle Cet al., 2003,

  In utero gene transfer of human factor IX to fetal mice can induce postnatal tolerance of the exogenous clotting factor

  , BLOOD, Vol: 101, Pages: 1359-1366, ISSN: 0006-4971
  • Cite
  • Citations: 63
• JOURNAL ARTICLE
  Wong KK, Carpenter M, Young LL, Walker SJ, McKenzie G, Rust A, Ward G, Packwood L, Wahl K, Delriviere L, Hoyne G, Gibbs P, Champion BR, Lamb JR, Dallman MJet al., 2003,

  Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8(+) cell-dependent mechanism

  , JOURNAL OF CLINICAL INVESTIGATION, Vol: 112, Pages: 1741-1750, ISSN: 0021-9738
  • Author Web Link
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  • Citations: 59
• JOURNAL ARTICLE
  Lowrey JA, Stewart GA, Lindey S, Hoyne GF, Dallman MJ, Howie SEM, Lamb JRet al., 2002,

  Sonic hedgehog promotes cell cycle progression in activated peripheral CD4(+) T lymphocytes

  , JOURNAL OF IMMUNOLOGY, Vol: 169, Pages: 1869-1875, ISSN: 0022-1767
  • Author Web Link
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  • Citations: 75
• JOURNAL ARTICLE
  Stewart GA, Lowrey JA, Wakelin SJ, Fitch PM, Lindey S, Dallman MJ, Lamb JR, Howie SEMet al., 2002,

  Sonic hedgehog signaling modulates activation of and cytokine production by human peripheral CD4(+) T cells

  , JOURNAL OF IMMUNOLOGY, Vol: 169, Pages: 5451-5457, ISSN: 0022-1767
  • Author Web Link
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  • Citations: 77
• JOURNAL ARTICLE
  Tian LN, Guo WH, Yuan ZW, Lui VCH, Chan JKY, Yagita H, Akiba H, Dallman M, Tam PKHet al., 2002,

  Association of the CD134/CD134L costimulatory pathway with acute rejection of small bowel allograft

  , TRANSPLANTATION, Vol: 74, Pages: 133-138, ISSN: 0041-1337
  • Author Web Link
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  • Citations: 5
• JOURNAL ARTICLE
  Bugeon L, Hargreaves REG, Crompton T, Outram S, Rahemtulla A, Porter ACG, Dallman MJet al., 2001,

  Selective silencing of full-length CD80 but not IgV-CD80 leads to impaired clonal deletion of self-reactive T cells and altered regulation of immune responses

  , EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 31, Pages: 118-127, ISSN: 0014-2980
  • Author Web Link
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  • Citations: 4
• CONFERENCE PAPER
  Guo WH, Tian L, Chan KL, Dallman M, Tam PKHet al., 2001,

  Role of CD4+and CD8+T cells in early and late acute rejection of small bowel allograft

  , 47th Annual Congress of the British-Association-of-Paediatric-Surgeons, Publisher: W B SAUNDERS CO, Pages: 352-356, ISSN: 0022-3468
  • Author Web Link
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  • Citations: 9

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