Programme leads


Professor Paul MatthewsProfessor Paul Matthews

Exploring glial-neuronal interactions at the transition from brain vulnerability to pathology

Paul Matthews, OBE, DPhil, FRCP, FMedSci is the Edmond and Lily Safra Professor of Translational Neuroscience and Therapeutics, an Associate Director of the UK Dementia Research Institute and Lead for the UK DRI at Imperial College. Since 2009, he has been on the Steering Committee of UK Biobank and chairs the Imaging Enhancement Working Group, which has supported UK Biobank for creating the world’s largest population research imaging resource.

Previously, Matthews spent almost nine years as a Vice President in GlaxoSmithKline, holding a variety of senior portfolios, including those for the GSK Clinical Imaging Centre and the later Global Imaging Group. He jointly founded and was the first Director of Oxford FMRIB Centre (1995-2005). He is a Fellow by Special Election of St Edmund Hall, Oxford, a Fellow of the Academy of Medical Sciences, and a Fellow of the Academea Europea. He was awarded an OBE in 2008 for services to Neuroscience.

He is an NIHR Senior Investigator. His research addresses mechanisms of failure of glial-neuronal homeostatic mechanisms in the early stages of Alzheimer’s disease and in progressive multiple sclerosis. He always is pleased to hear from interested prospective students, scientists or others who share a common interest in helping science improve the lives of people with dementia and those of their families.

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Wisden, WilliamProfessor William Wisden

The role of sleep in protecting against amyloid and glial pathology in dementia

 Professor Wisden is interested in three major problems in neuroscience:

- Why do we sleep and how is sleep initiated and maintained?
- What are the molecular and neuronal mechanisms underlying the loss of consciousness induced by general anaesthetics? And,
- What is the molecular basis of neuropathic pain?

He uses a wide variety of techniques and model systems to investigate these problems, including confocal microscopy, real-time PCR, proteomic analysis with mass spectrometry and structural biology.

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Elliott, PaulProfessor Paul Elliott

Linking genetic, epidemiology and metabolic phenotyping in dementia in the context of ageing, environment and lifestyle

Professor Paul Elliott, MBBS, PhD, FMedSci, trained in clinical medicine and epidemiology as a Wellcome Trust Clinical Fellow at St Mary's Hospital London and the London School of Hygiene and Tropical Medicine. He studied for his PhD in Epidemiology on the INTERSALT Study under the mentorship of Professor Geoffrey Rose. He remained at the London School working as a lecturer, and subsequently as senior lecturer and reader in epidemiology before being appointed as Head of the Environmental Epidemiology Unit at LSHTM 1990. In 1995 he was appointed to the Chair in Epidemiology and Public Health Medicine at Imperial College London. 

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Grossman, NirDr Nir Grossman

Developing novel bioelectronics technologies to modulate neurons and glia in the study of sleep, neuroprotection and cognition

Dr Grossman develops neuromodulatory interventions for brain disorders by pioneering new tools and principles to impact the disease pathology via direct modulation of the underlying aberrant neural activity.

His research drives innovation through rigorous scientific exploration of common biophysical principles and rules underpinning the neural processing of electromagnetic stimulation, using natural bridges between advanced computational neuroscience and cutting-edge experiments, ranging from a single neuron cell to human behaviour.

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Samuel BarnesDr Samuel Barnes

Exploring the role of neural circuit plasticity in the susceptibility of the aged brain to neurodegeneration

Dr Barnes investigates why the aged brain is vulnerable to neurodegeneration in order to identify strategies that may alleviate this susceptibility.

His group focuses on homeostatic neural plasticity processes which are thought to be critical for healthy network function. The group uses a combination of voltage and calcium imaging, bioelectronics and electrophysiology to determine the efficiency and mechanisms of homeostatic plasticity processes in both the aged brain and the early stages of neurodegeneration.

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Marco BrancaccioDr Marco Brancaccio

Exploring the role of circadian dysfunction in the early stages of dementia

Dr Brancaccio investigates the molecular, cellular and circuit mechanisms underlying circadian function in health and disease.

His group focuses on understanding the mechanisms driving circadian misregulation in the early stages of dementia. His laboratory uses a wide range of techniques including live imaging and in vivo gene therapy to study and harness circadian brain function with the aim of delaying disease onset and progression.

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Yu YeDr Yu Ye

Protein homeostasis in cell stress

Dr Ye completed his PhD at MRC-LMB, and held a Junior Research Fellowship and a Sir Henry Wellcome Fellowship at University of Cambridge and Harvard Medical School. He is excited to return to his alma mater, where he will untangle the molecular agents causing dementia with the ubiquitin-proteasome system.

The Ye Lab studies the interplay between the ubiquitin-proteasome system and amyloid proteins in biological systems. Using advanced fluorescence imaging techniques, the lab seeks to uncover the cellular mechanisms of restricting or reversing protein aggregation, and how malfunction of this system leads to neurodegenerative disorders.

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Nathan SkeneDr Nathan Skene is an Edmond and Lily Safra Research Fellow at the UK DRI. 

Nathan Skene completed his undergraduate degree in Artificial Intelligence and Cybernetics at the University of Reading, followed by an MPhil in Computational Biology at Cambridge. His PhD was at the Sanger Institute working with Prof Seth Grant on the Genes2Cognition programme. During his PhD he worked on analysing the transcriptomic changes seen in a mice carrying a wide range of synaptic mutations.

His interests lie in using human genetics to gain insight into the neurobiology of brain disorders and cognitive traits. He did his postdoc in the lab of Jens Hjerling-Leffler at the Karolinska Institutet, where he developed a series of method which made it possible to identify cell types underlying complex diseases using GWAS data. 

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Dr Sarah MarziDr Sarah Marzi is an Edmond and Lily Safra Research Fellow at the UK DRI 

Dr Marzi uses genome-wide genetic and epigenetic techniques as well as innovative bioinformatic and statistical approaches to investigate epigenetic dysregulation in disease

 

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Management team


Management team

Multi-'omics Atlas Project (MAP) team


Multi-'omics Atlas Project (MAP) team

Dr Johanna Jackson

Jo Jackson

Dr Johanna Jackson
Scientific Lead

Hannah Gowland

Hannah Gowland

Hannah Gowland
Project Officer

Dr Amy Smith

Amy Smith

Dr Amy Smith
Research Associate

Karen Davey

Karen Davey

Karen Davey
Research Assistant

Dr Combiz Khozoie

Combiz

Dr Combiz Khozoie
Senior Bioinformaticist

Dr Nathan Skene

Nathan Skene

Dr Nathan Skene
Research Fellow

Dr Mahdi Moradi Majaneh

Mahdi

Dr Mahdi Moradi Majaneh
Senior Bioinformaticist

Dr Nurun Fancy

Nurun Fancy

Dr Nurun Fancy
Bioinformaticist

Nanet Willumsen

Nanet

Nanet Willumsen
Research Technician

Aisling McGarry

Aisling

Aisling McGarry
Research Technician

Callum Muirhead

Callum

Callum Muirhead
Research Technician

Research staff


Research staff

Ketevan Alania

Kety Alania

Ketevan Alania
Research Assistant

Dr Berta Anuncibay Soto

Berta Anuncibay Soto

Dr Berta Anuncibay Soto
Research Associate in Sleep & Neurodegeneration

Karen Davey

Karen Davey

Karen Davey
Research Assistant

Dr Nurun Fancy

Dr Nurun Fancy

Dr Nurun Fancy
Research Associate

Dr Helen Huang

Dr Helen Huang

Dr Helen Huang
Research Associate

Manuja Kaluarchchi

Manuja Kaluarachchi

Manuja Kaluarchchi
Project Manager in Metabolomics

Junheng Li

Junheng Li

Junheng Li
Research Postgraduate

Dr Mahdi Moradi Marjaneh

Mahdi

Dr Mahdi Moradi Marjaneh
Senior Scientist in Bioinformatics

Callum Muirhead

Callum Muirhead

Callum Muirhead
Research Technician

Dr Matthieu Nollet

Mathieu Nollet

Dr Matthieu Nollet
Research Associate

Dr Nawal Zabouri

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Dr Nawal Zabouri
Neural Circuit Plasticity Lab Manager

Xiaoqi Zhu

Xiaoqi Zhu

Xiaoqi Zhu
Research Postgraduate

Associates and collaborators 


Associates and collaborators