Intensive care ward

Contact us

For any enquiries related to Sepsis, please contact

Professor Anthony Gordon

Part of the Critical care clinical area. See our research publications.


Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. It is very common worldwide, and has both a high mortality and morbidity rate. In the UK alone, more than 120,000 patients are admitted to intensive care units (ICU) with sepsis each year and the NHS spends more than £2billion caring for them.

Our group conducts translational research in sepsis and includes the whole spectrum of research from early laboratory work through to large-scale national and international clinical trials. The overall goal is to develop our novel basic science discoveries, into effective diagnostic and treatment strategies that change and improve clinical care of critically ill patients.

Summary of current research

Our overall aim is to improve outcomes for patients and their relatives who have sepsis. We know that sepsis is a heterogeneous syndrome. Many attempts to develop new treatment strategies have failed due, in part, to grouping all sepsis patients together, based on similar but non-specific clinical characteristics. We aim to address this through:

  • Better understanding of the immunological changes in sepsis, focusing on monocyte and microvesicle biology
  • Investigating the genomic, transcriptomic and metabonomic effects and changes in septic patients
  • Developing novel diagnostic clinical tests to improve the management of septic patients
  • Developing new treatments to manage septic patients
  • Combining these novel diagnostics with new and existing treatments in clinical trials, developing a personalised medicine approach, thus allowing us to give the right patient, the right treatment, at the right time and with right dose

Key members within Sepsis

Funders and collaborators

Clinical trials