PET scanner


Group lead
Dr Matthew Williams
+44 (0)20 3311 0733

Related themes

Disease areas

What we do

We conduct research in both Computational and Academic Clinical Oncology.  The former ranges across mathematical and computational approaches to improving healthcare, particularly using clinical big data, as well as novel reasoning techniques to better understand clinical trials and clinical data. We are also working on generating clinical data using patient-worn sensors and online data collection platforms. Our clinical oncological research focuses on our areas of expertise; lung, brain and breast cancer, as well as technical developments in radiotherapy.

Why it is important

Computational medicine offers a chance to provide mass-personalisation of medicine, improving healthcare and preventing harm. However, many of the underlying techniques and theory are often poorly developed in the medical arena, where we face problems of complex, longitudinal datasets with conflicting and incomplete data.

Radiotherapy remains a key modality in the treatment of cancer, with over half of all cancer patients receiving radiotherapy at some point in their illness. Our work is dedicated to improving the basic science, underpinning the delivery of radiotherapy and conducting clinical trials to assess the impact of radiotherapy in practice. 

How it can benefit patients

We have a strong translational aspect to our work. We are currently developing patient-focused extensions to our previous work to develop patient and doctor-enabling tools to reason with clinical trials. We are also developing novel uses for patient-worn sensors in order to better understand toxicity and quality of life in patients being treated for their cancer, with the ultimate aim of improving patient outcomes.  

We are also running over 20 randomised clinical trials in radiotherapy, across a range of different types of cancers. We are also leading the development of novel radiotherapy technology, in conjunction with colleagues in the High-Energy Physics Department at Imperial College, and the analysis of national radiotherapy data techniques.

Summary of current research

Computational Oncology

  • Clinical Big Data: Using national-scale datasets to understand and improve healthcare at large scale
  • Computational Argumentation: Using novel computational methods to understand and reason with clinical trial data
  • Patient-generated Electronic Data: Using patient wearables and online platforms to gather high-resolution patient data at low cost

Clinical Oncology

  • Data and information
  • Accelerator development
  • Technical breast radiotherapy
  • Clinical trial development and leadership



Please see the following page for more information about the delivery of clinical radiotherapy services at Imperial.

Clinical trials

We are involved in multiple clinical trials and are interested in the application of computational techniques to improve patient healthcare.  Please contact group lead for more information. 

PhD students

When we have funding for PhD studentships, we advertise them through central channels such as Find a PhD. Information is also available on the Surgery and Cancer study page. If no studentships are currently advertised, please get in touch with the group lead with proposed project titles to discuss further. 

Our researchers

Dr Dorothy Maria Gujral

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Dr Dorothy Maria Gujral
Honorary Clinical Senior Lecturer

Miss Kerlann Le Calvez

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Miss Kerlann Le Calvez
Honorary Research Officer