Blood sample being takenGastroenterology supports one of the largest inflammatory bowel disease (IBD) clinics in London and through this conducts trials of biological therapies to aid in disease management. The investigators have an interest in the extra-intestinal manifestations of IBD. In addition, there is a research programme on small bowel transporter systems.

Gastro research themes

Bile Acid Diarrhoea (BAD)

Bile acid diarrhoea (BAD) is a common cause of chronic functional diarrhoea and accounts for around a third of patients with diarrhoea-predominant irritable bowel syndrome. However diagnostic rates are poor and there is a large unmet need is these patients. We have described how a key regulatory hormone, FGF19, is involved in the pathogenesis of BAD causing overproduction of bile acids. FGF19 transcription is impaired in these patients but can be stimulated using FXR-agonists and clinical trials of these and other agents are underway.

Lead: Professor Julian Walters

Gut dysbiosis

Our research uses integrated 'omics' technologies to explore the interactions between the gut microbiota and host metabolism in health and disease.  We are particularly interested in understanding the mechanism of novel therapies that may restore the structure and function of the healthy gut microbiota, including fecal transplantation as treatment for Clostridium difficile infection.

Co-leads: Dr Julian Marchesi and Dr Horace Williams

Gastro research themes

Gut Microbiome

In the last 15 years, it has become increasingly evident that the bacterial species which colonise the gut, play a role in disease and health. This interaction can either be direct with the host cells, but more commonly it is via the metabolites and proteins that the bacteria make while they grow in the gut. Many of these metabolites then traverse the gut cells and interact with the liver, and once past this organ the whole host. For further information on this area of research please contact:

Co-leads: Dr Julian Marchesi and Professor Elaine Holmes

Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is a term mainly used to describe two conditions, ulcerative colitis and Crohn's disease. For further information on this area of research please contact:

Co-leads: Professor Tim Orchard and Professor Ailsa Hart