Receptor signalling

Contact

For more information on this area of research

Dr Nick Dibb
+44 (0)20 7594 2103
n.dibb@imperial.ac.uk

What we do

Each of the receptor signalling groups within Reproductive and Developmental Medicine have their own research program, tackling key aspects of signalling control. They also engage in collaborative projects to study the fundamental biological processes and clinical problems related to receptor signalling.   

Why it is important

Hormones and other signalling molecules control all aspects of reproduction and work by binding to and activating receptors that are expressed by target cells within reproductive tissues.  Defects in the action of these receptors and the underlying signalling pathways are responsible for many of the problems of pregnancy, such as premature labour and metabolic disorders, including polycystic ovary syndrome.   Different defects of the same signalling pathways are also responsible for the development of ovarian cancer and other gynaecological malignancies.

Impact 

We have published important papers on the signalling pathways that control normal labour, the growth of follicles in ovaries, the growth of reproductive tissues and stem cells. We have also published key papers on their associated pathophysiology which includes premature labour, gynaecological malignancies and polycystic ovarian syndrome.  This work has led to the identification of better ways of diagnosing disease and of better drugs for disease treatment.  

Summary of current research

Lead researchers

Our researchers