Flow and aerosol deposition in the alveoli
Computational fluid dynamics (CFD) simulations provide an effective approach for examining the fluid flow and aerosol transport in the respiratory airways. However, while there have been numerous numerical studies of aerosol transport in the conducting airways, few have focused on the alveolar region of the lung. Furthermore, the studies to date have adopted rigid-walled alveolar duct structures and simplified geometrical models.
Our work will adopt realistic alveolar geometries, obtained from micro-CT scans, and model the alveolar wall movement during breathing. The results from this work will be beneficial in understanding the impact of changes in the alveolar geometry on efficiency of drug delivery and its dependence on the size of the aerosol particles.