Our research spans accross five research themes:
Gut brain axis
The actions of the gut microbiota are not confined to the gut and the liver, to which the blood from the gut drains and is processed. There is a body of work building which shows that the gut microbiota can play a role as a driver of behaviour, stress response and some brain diseases, such as dementia.
Our work 2
Whilst the liver is seen as the major organ for drug metabolism in the body it is often forgotten that the gut microbiotoa also undertakes a range of important biotransformations on drugs and pharmacologically active dietary products. In particular the gut microbiota are adept at reductive drug metabolism and this can be essential for the efficacy of drugs such as sulpasalazine which is a prodrug of 5-aminosalicylic acid used in the treatment of ulcerative colitis and inflammatory bowel conditions.