The Centre has a long history of developing new techniques for medical imaging (particularly in magnetic resonance imaging), transforming them from a primarily diagnostic modality into an interventional and therapeutic platform. This is facilitated by the Centre's strong engineering background in practical imaging and image analysis platform development, as well as advances in minimal access and robotic assisted surgery. Hamlyn has a strong tradition in pursuing basic sciences and theoretical research, with a clear focus on clinical translation.

In response to the current paradigm shift and clinical demand in bringing cellular and molecular imaging modalities to an in vivo – in situ setting during surgical intervention, our recent research has also been focussed on novel biophotonics platforms that can be used for real-time tissue characterisation, functional assessment, and intraoperative guidance during minimally invasive surgery. This includes, for example, SMART confocal laser endomicroscopy, time-resolved fluorescence spectroscopy and flexible FLIM catheters.

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    Zhao L, Giannarou S, Lee S, Merrifield R, Yang GZet al., 2016,

    Intra-operative simultaneous catheter and environment modelling for endovascular navigation based on intravascular ultrasound, electromagnetic tracking and pre-operative data

    , The Hamlyn Symposium on Medical Robotics, Publisher: The Hamlyn Symposium on Medical Robotics, Pages: 76-77
    Zhao L, Giannarou S, Lee S-L, Yang G-Zet al., 2016,

    SCEM+: Real-Time Robust Simultaneous Catheter and Environment Modeling for Endovascular Navigation

    , IEEE ROBOTICS AND AUTOMATION LETTERS, Vol: 1, Pages: 961-968, ISSN: 2377-3766
    Zhao L, Giannarou S, Lee SL, Yang GZet al., 2016,

    Registration-free simultaneous catheter and environment modelling

    , Pages: 525-533, ISSN: 0302-9743

    © Springer International Publishing AG 2016. Endovascular procedures are challenging to perform due to the complexity and difficulty in catheter manipulation. The simultaneous recovery of the 3D structure of the vasculature and the catheter position and orientation intra-operatively is necessary in catheter control and navigation. State-of-art Simultaneous Catheter and Environment Modelling provides robust and real-time 3D vessel reconstruction based on real-time intravascular ultrasound (IVUS) imaging and electromagnetic (EM) sensing,but still relies on accurate registration between EM and pre-operative data. In this paper,a registration-free vessel reconstruction method is proposed for endovascular navigation. In the optimisation framework,the EM-CT registration is estimated and updated intra-operatively together with the 3D vessel reconstruction from IVUS,EM and pre-operative data,and thus does not require explicit registration. The proposed algorithm can also deal with global (patient) motion and periodic deformation caused by cardiac motion. Phantom and invivo experiments validate the accuracy of the algorithm and the results demonstrate the potential clinical value of the technique.

    Zhou X, Riga C, Yang G, Lee Set al., 2016,

    3D Shape Recovery of Deployed Stent Grafts from a Single X-ray Image based on Newly Designed Markers

    , MICCAI Workshop on CVII-STENT 2016
    Zhou X, Yang GZ, Riga C, Lee Set al., 2016,

    Stent graft shape instantiation for fenestrated endovascular aortic repair

    , The Hamlyn Symposium on Medical Robotics, Publisher: The Hamlyn Symposium on Medical Robotics, Pages: 78-79

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