A primary motivation of our research is the monitoring of physical, physiological, and biochemical parameters - in any environment and without activity restriction and behaviour modification - through using miniaturised, wireless Body Sensor Networks (BSN). Key research issues that are currently being addressed include novel sensor designs, ultra-low power microprocessor and wireless platforms, energy scavenging, biocompatibility, system integration and miniaturisation, processing-on-node technologies combined with novel ASIC design, autonomic sensor networks and light-weight communication protocols. Our research is aimed at addressing the future needs of life-long health, wellbeing and healthcare, particularly those related to demographic changes associated with an ageing population and patients with chronic illnesses. This research theme is therefore closely aligned with the IGHI’s vision of providing safe, effective and accessible technologies for both developed and developing countries.

Some of our latest works were exhibited at the 2015 Royal Society Summer Science Exhibition.


Citation

BibTex format

@article{Chabloz:2019:10.1002/chem.201901820,
author = {Chabloz, N and Wenzel, M and Perry, H and Yoon, I and Molisso, S and Stasiuk, G and Elson, D and Cass, A and Wilton-Ely, J},
doi = {10.1002/chem.201901820},
journal = {Chemistry - A European Journal},
pages = {10895--10906},
title = {Polyfunctionalised nanoparticles bearing robust gadolinium surface units for high relaxivity performance in MRI},
url = {http://dx.doi.org/10.1002/chem.201901820},
volume = {25},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - The first example of an octadentate gadolinium unit based on DO3A (hydration number q = 1) with a dithiocarbamate tether has been designed and attached to the surface of gold nanoparticles (around 4.4 nm in diameter). In addition to the superior robustness of this attachment, the restricted rotation of the Gd complex on the nanoparticle surface leads to a dramatic increase in relaxivity (r1) from 4.0 mM1 s1 in unbound form to 34.3 mM1 s1 (at 10 MHz, 37 °C) and 22 ± 2 mM1s1 (at 63.87 MHz, 25 °C) when immobilised on the surface. The ‘onepot’ synthetic route provides a straightforward and versatile way of preparing a range of multifunctional gold nanoparticles. The incorporation of additional surface units improving biocompatibility (PEG and thioglucose units) and targeting (folic acid) lead to little detrimental effect on the high relaxivity observed for these nontoxic multifunctional materials. In addition to the passive targeting attributed to gold nanoparticles, the inclusion of a unit capable of targeting the folate receptors overexpressed by cancer cells, such as HeLa cells, illustrates the potential of these assemblies.
AU - Chabloz,N
AU - Wenzel,M
AU - Perry,H
AU - Yoon,I
AU - Molisso,S
AU - Stasiuk,G
AU - Elson,D
AU - Cass,A
AU - Wilton-Ely,J
DO - 10.1002/chem.201901820
EP - 10906
PY - 2019///
SN - 0947-6539
SP - 10895
TI - Polyfunctionalised nanoparticles bearing robust gadolinium surface units for high relaxivity performance in MRI
T2 - Chemistry - A European Journal
UR - http://dx.doi.org/10.1002/chem.201901820
UR - https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201901820
UR - http://hdl.handle.net/10044/1/70676
VL - 25
ER -