Lupus nephritis

Investigating the causes and mechanisms of organ damage in a range of autoimmune and inflammatory conditions

The Centre for Inflammatory Disease brings together a diverse group of clinical and non-clinical experts who study the causes and mechanisms of organ damage in a range of autoimmune and inflammatory conditions.

Key research areas include autoimmunity, complement, macrophage biology, tumour immunology, vascular inflammation, skin immunology and renal pathology. Our methodologies range from in vitro approaches; in vivo modelling of inflammation and autoimmunity; clinical trials and systems biology. Clinically we have expertise in Systemic Lupus Erythematosus; C3 glomerulopathy; Glomerulonephritis, Diabetic nephropathy, Chronic kidney disease, Chronic Granulomatous Disease and Vasculitis.

Funding sources include the Wellcome Trust, Medical Research Council, Versus Arthritis, British Heart Foundation, Kidney Research UK, and the National Institute for Health Research.


Centre leads

  • Professor Charles Pusey

    Professor Charles Pusey

    Personal details

    Professor Charles Pusey Co-Director

    +44 (0)20 3313 2308

    Bio

    Charles Pusey is Professor of Medicine, and Honorary Consultant Physician in the Renal Directorate at Imperial College Healthcare NHS Trust.  He is a clinician scientist with a particular interest in autoimmune renal disease, including primary systemic vasculitis. 

    Location

    5N2, Commonwealth Building, Hammersmith Campus

  • Professor Matthew Pickering

    Professor Matthew Pickering

    Personal details

    Professor Matthew Pickering Co-Director

    +44 (0)20 3313 2315

    Bio

    Matthew Pickering is Professor of Rheumatology and a Wellcome Trust Senior Fellow in Clinical Science. His research interest is complement and the kidney and his clinical expertise includes systemic lupus erythematous and complement deficiency states.

    Location

    9N12, Commonwealth Building, Hammersmith Campus

Principal Investigators

  • Dr Jacques Behmoaras

     Dr Jacques Behmoaras

    Personal details

    Dr Jacques Behmoaras Senior Lecturer

    +44 (0)20 3313 2339

    Bio

    Jacques Behmoaras is a Senior Lecturer. His group applies systems-genetics approaches in macrophage immune function and metabolism related to complex inflammatory diseases.

    Location

    9N13, Commonwealth Building, Hammersmith Campus

  • Professor Marina Botto

    Marina Botto

    Personal details

    Professor Marina Botto Director of Bioservices, Professor of Rheumatology

    +44 (0)20 3313 2316

    Bio

    Marina Botto is Professor of Rheumatology and Honorary Consultant at Imperial College Healthcare NHS Trust.  She is also the Director of Bioservices at Imperial College London. Her research focuses on complement biology and autoimmunity, specifically systemic lupus erythematous. 

    Location

    9N10, Commonwealth Building, Hammersmith Campus

  • Professor Terence Cook

    Terry Cook

    Personal details

    Professor Terence Cook Professor of Renal Pathology

    +44 (0)20 3313 2009

    Bio

    Terence Cook is Professor of Renal Pathology and Honorary Consultant Renal Pathologist in North West London Pathology. His research interests are mechanisms of kidney injury in glomerular disease, particularly glomerulonephritis associated with abnormal control of complement activation.

    Location

    9N9, Commonwealth Building, Hammersmith Campus

  • Professor Liz Lightstone

    Professor Liz Lightstone

    Personal details

    Professor Liz Lightstone Professor of Renal Medicine

    +44 (0)20 3313 2309

    Bio

    Liz Lightstone is Professor of Renal Medicine and Honorary Consultant Physician in the Renal Directorate at Imperial College Healthcare NHS Trust. She undertakes translational research in glomerulonephritis, notably lupus nephritis and C3GN, as well as in pregnancies in women with kidney diseases.

    Location

    5S5e, Commonwealth Building, Hammersmith Campus

  • Dr Stephen McAdoo

    Steve McAdoo

    Personal details

    Dr Stephen McAdoo Imperial Clinician Researcher (Fellowship)

    Bio

    Dr Stephen McAdoo holds an Imperial College Clinician Researcher Fellowship, and is an Honorary Consultant Nephrologist at Imperial College Healthcare NHS Trust. His clinical and research interests are in autoimmune kidney diseases, with a particular focus on crescentic glomerulonephritis and systemic vasculitis.

    Location

    Renal Medicine, Hammersmith Hospital, Hammersmith Campus

  • Dr James Peters

    James Peters

    Personal details

    Dr James Peters Reader in Immunology and Inflammation

    Bio

    James Peters is a Reader in Immunology and Inflammation and Honorary Consultant in Rheumatology. He is a clinician scientist interested in the interface of inflammation and vascular disease, and has a specialist clinical practice in vasculitis and lupus. 

    Location

    Commonwealth Building, Hammersmith Campus

  • Dr Candice Roufosse

    Candice Roufosse

    Personal details

    Dr Candice Roufosse Clinical Senior Lecturer

    +44 (0)20 3313 3280

    Bio

    Dr Candice Roufosse is Senior Clinical Lecturer and Honorary Consultant in Renal and Transplant Cellular Pathology North West London Pathology (affiliated to Imperial College Healthcare NHS Trust). She carries out translational research in renal and transplant pathology.

    Location

    Commonwealth Building, Hammersmith Campus

  • Dr Sophie Rutschmann

    Sophie Rutschmann

    Personal details

    Dr Sophie Rutschmann Senior Lecturer

    +44 (0)20 3313 8213

    Bio

    Sophie Rutschmann is a non-clinical Senior Lecturer with a research background in genetics and immunology. In the Department, she leads the MSc Immunology and advises on the education strategy. In the Faculty of Medicine, she is the Academic Lead for Postgraduate Education.

    Location

    9N4b, Hammersmith Hospital, Hammersmith Campus

  • Professor Frederick Tam

    Professor Fred Tam

    Personal details

    Professor Frederick Tam Ken and Mary Minton Chair of Renal Medicine

    +44 (0)20 3313 2354

    Bio

    Professor Frederick Tam is the Ken and Mary Minton Chair of Renal Medicine. He has been developing non-invasive biomarkers and novel anti-inflammatory therapies for kidney diseases, including diabetic nephropathy, glomerulonephritis and rejection of kidney transplant. His group integrates laboratory mechanistic study w...

    Location

    5N, 8C, Commonwealth Building, Hammersmith Hospital, Hammersmith Campus

  • Dr Jessica Strid

    Jessica Strid

    Personal details

    Dr Jessica Strid Reader in Cellular Immunology

    +44 (0)20 3313 1475

    Bio

    Jessica Strid is a Reader in Cellular Immunology. Her research group studies immune-surveillance in epithelial tissues, principally the skin, and focus on understanding the role of tissue resident immune cells in regulating epithelial cell homeostasis, repair and carcinogenesis.

    Location

    9N15B, Commonwealth Building, Hammersmith Campus

  • Dr Michelle Willicombe

    Dr Michelle Willicombe

    Personal details

    Dr Michelle Willicombe Clinical Senior Lecturer

    Bio

    Dr Michelle Willicombe is a Senior Clinical Lecturer and Honorary Consultant Nephrologist at Imperial College Healthcare NHS Trust, with clinical expertise in transplantation. Her research interest is in the prevention and treatment of antibody-mediated transplant rejection.

    Location

    Commonwealth Building, Hammersmith Campus

  • Dr Kevin Woollard

    Dr Kevin Woollard

    Personal details

    Dr Kevin Woollard Honorary Senior Lecturer

    +44 (0)20 3313 2357

    Bio

    Dr Woollard is Honorary Senior Lecturer and Principal Scientist, Pre-clinical Renal Bioscience Lead at AstraZeneca (Cambridge). His lab studies the immunobiology of inflammatory kidney and reno-cardiac disease.

    Location

    9N15C, Commonwealth Building, Hammersmith Campus

  • Dr David Thomas

    David Thomas

    Personal details

    Dr David Thomas Reader in Immunology and Inflammation (Clinical)

    +44 (0)20 3313 8506

    Bio

    David Thomas is a Reader in Immunity and Inflammation and Wellcome-Beit Prize Clinical Research Career Development Fellow. His laboratory focuses on the biology of EROS, a protein that he has shown is essential for the phagocyte respiratory burst in mouse and human. 

    Location

    9NC, 9th Floor, Commonwealth Building, Hammersmith Campus

  • Dr Eleanor Sandhu

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    Personal details

    Dr Eleanor Sandhu Imperial Post-CCT Research Fellow

    +44 (0)20 3313 3980

    Bio

    Dr Eleanor Sandhu is a Clinical Research Fellow and Honorary Consultant Nephrologist at Imperial College Healthcare NHS Trust. Her research interest is in the neurobiology of the body-brain axis in modifying salt intake and its translation to the clinical care of renal patients.

    Location

    5N8A, 5th Floor, Commonwealth Building, Hammersmith Campus

  • Dr Nick Medjeral-Thomas

    Dr Nick Medjeral-Thomas

    Personal details

    Dr Nick Medjeral-Thomas IPPRF - Post-Doctoral and Post-CCT Research Fellowship

    +44 (0)20 3313 2318

    Bio

    Nick Medjeral-Thomas is a Clinical Research Fellow and Nephrologist at Imperial College London. His research interest is the contribution of complement activity to glomerular kidney disease, with a focus on IgA nephropathy and C3 glomerulopathy.

    Location

    9N15, 9th Floor, Commonwealth Building, Hammersmith Campus