Molecular immunology

Exploring key molecular pathways in autoimmunity, inflammation and cancer

The Centre for Molecular Immunology and Inflammation studies the key molecular pathways that drive and regulate autoimmune/inflammatory diseases and cancer. This research utilises a broad range of approaches, including genetic screens, biochemical analysis of signalling pathways, biophysical and structural analyses, ‘omics’ technologies and drug discovery. Conditional genetic models and patient investigations are used to dissect the function of the molecular pathways studied in autoimmunity and cancer. The overarching goal is to develop new therapies through increased mechanistic understanding at the molecular level.

Key research areas include haematological and solid cancers, psoriasis and inflammatory bowel disease.

Funding sources have included the Medical Research Council, Cancer Research UK, Bloodwise, British Heart Foundation, National Psoriasis Foundation, the National Institutes of Health and the NIHR Imperial BRC.

Centre leads

  • Professor Steven Ley

    Professor Steven Ley

    Personal details

    Professor Steven Ley Co-Director, Centre for Molecular Immunology and Inflammation

    +44 (0)20 8816 2463

    Bio

    Steve Ley is Professor and Chair of Molecular Immunology. His group studies the regulation and function of key MAP kinase and NF-kB signalling pathways in inflammation and immunity.

    Location

    Commonwealth Building, Hammersmith Campus

  • Professor Guido Franzoso

    Professor Guido Franzoso

    Personal details

    Professor Guido Franzoso Co-Director, Centre for Molecular Immunology and Inflammation

    +44 (0)20 3313 8421

    Bio

    Guido Franzoso is Professor and Chair of Signal Transduction and Inflammation and holds an Honorary position at Imperial College NHS Trust. His research interest is the regulation and function of NF-κB transcription factors.

    Location

    10N8, Commonwealth Building, Hammersmith Campus

Principal Investigators

  • Professor Danny Altmann

    Danny Altmann

    Personal details

    Professor Danny Altmann Professor of Immunology

    +44 (0)20 3313 8212

    Bio

    Danny Altmann heads a lab at the Hammersmith Hospital Campus of Imperial, with expertise in the HLA system, antigen discovery, T cell subsets and NK cells.

    Location

    7S7, Hammersmith Hospital, Hammersmith Campus

  • Professor Victor Tybulewicz

    Victor Tybulewicz

    Personal details

    Professor Victor Tybulewicz Affiliated Principal Investigator (Francis Crick Institute)

    +44 (0)20 3796 1612

    Bio

    Professor Victor Tybulewicz is a Senior Group Leader and Associated Research Director at the Francis Crick Institute and a Professor at Imperial College. Read full details of Professor Tybulewicz's research interests .

    Location

    L2-2720, Francis Crick Institute, The Francis Crick Institute