Imperial scientists are at the forefront of global efforts to protect the world from the Covid-19 coronavirus outbreak.  Professor Robin Shattock heads one of the few labs in the world developing a coronavirus vaccine. Professor Shattock’s vaccine is due to shortly enter animal trials - and could lead to human trials in as little as five months.

Working at the interface between clinician-scientists, health care workers and basic sciences, this pillar will cross programs of research from bench to bedside (translation) and bedside to bench (clinical samples), taking discoveries made in immunology, cell biology and molecular biology, often derived directly from clinical samples, and building on these to inform interventions or drive human clinical trials with vaccines, drugs, novel diagnostics or biosensors.

Our clinical & health sciences champions

  • Professor Wendy Barclay

    Professor Wendy Barclay

    Personal details

    Professor Wendy Barclay Action Medical Research Chair Virology, Head of Department of Infectious Disease

    Research interests

    Respiratory viruses, in particular influenza and, most recently, SARS-CoV-2. Studies in the lab aim to understand the molecular and cellular basis of the pathogenesis, host range restrictions and viral transmissibility using genetic techniques to generate recombinant viruses and human airway models.

  • Dr Abigail Clements

    Dr Abigail Clements

    Personal details

    Dr Abigail Clements Lecturer - Department of Life Sciences

    Research interests

    Bacterial pathogenesis, in particular enteric pathogens Shigella, E. coli and emerging nosocomial pathogen Klebsiella pneumoniae . Comparing molecular mechanisms used by these pathogens to establish host infection using a combination of genetic, biochemical, bioinformatic and cell-based techniques.

  • Dr Céire Costelloe

    Dr Ceire Costelloe

    Personal details

    Dr Céire Costelloe Senior Lecturer and Director of Global Digital Health Unit

    Research interests

    Addressing key questions in infection-related and antimicrobial-resistant infection (AMR), in particular evaluating interventions targeting AMR using routinely collected clinical data and novel statistical causal inference methods.

  • Professor Michael Levin

    Professor Michael Levin

    Personal details

    Professor Michael Levin Chair in Paediatrics & International Child Health

    Research interests

    Diagnosis and treatment of a range of childhood infections including meningococcal disease, tuberculosis, bacterial sepsis and Kawasaki disease. Currently leads the EU funded DIAMOND study investigating the application of RNA transcriptomics to improve diagnosis of childhood infection.

  • Professor Peter Openshaw

    Professor Peter Openshaw

    Personal details

    Professor Peter Openshaw Senior Consul, Professor of Experimental Medicine

    Research interests

    How the immune system both protects against viral infection but also causes disease. A long-standing interest in RSV, influenza and, most recently, SARS-CoV-2, with his leadership of the PREPARE EU consortium and ISARIC4C collaborative network focussed on COVID in the UK.

  • Dr John Tregoning

    Dr John Tregoning

    Personal details

    Dr John Tregoning Reader in Respiratory Infections

    Research interests

    Developing a range of in vivo and in vitro models of infection and vaccination in early life, including RSV, Influenza, Pseudomonas aeruginosa , Staphylococcus aureus and Acinetobacter baumannii . They are using this approach to develop a broader understanding of respiratory infections and guide the design of vaccines.