The UK Dementia Research Institute (UK DRI) is seeking an outstanding Research Associate in Molecular Epidemiology interested in taking on a challenging role with considerable scope for independent scientific achievement and personal growth. The ideal candidate will be passionate about tackling big problems and be ready to try out high-risk, high-payoff projects. UK DRI at Imperial has been established to address a medical research area of...
Job listing information
- Reference MED01612
- Date posted 16 July 2020
- Closing date 16 August 2020
The UK Dementia Research Institute (UK DRI) is seeking an outstanding Research Associate in Molecular Epidemiology interested in taking on a challenging role with considerable scope for independent scientific achievement and personal growth. The ideal candidate will be passionate about tackling big problems and be ready to try out high-risk, high-payoff projects.
UK DRI at Imperial has been established to address a medical research area of the highest importance and future impact. As one of seven national centres of excellence embedded in major UK universities, we intend to transform the diagnosis, treatment and care of people with dementias. The Medical Research Council and charity partners the Alzheimer's Society and Alzheimer’s Research UK have invested £290m in fulfilment of the ambition identified in the Prime Minister's 2020 Challenge on Dementia.
The job environment will offer a career structure within the Department of Epidemiology and Biostatistics for a biostatistician with a deep interest in fundamental scientific challenges and the application of advanced and novel biostatistical methodologies to solve diverse biomedical problems.
Duties and responsibilities
As the successful candidate you will study genetic and metabolic determinants as well as a wide range of lifestyle factors in relation to the underlying cardio-metabolic risk factors, cognitive changes, sleep disturbances, shift patterns, mild cognitive impairment, the dementias and neurodegenerative diseases in large well-established population cohorts from UK, USA and Europe. Moreover, we will study the metabolic fingerprints of the genetic variants identified for Alzheimer’s disease and other neurodegenerative diseases, in blood and urine. The identified metabolic signals will be structurally identified and will be applied in networked pathway analysis to highlight metabolic pathways that underlie cognitive changes, dementias, Alzheimer’s disease and other neurodegenerative diseases. The identified metabolites will further be measured in CSF of people with mild cognitive impairment and cases of Alzheimer’s disease. The analysis includes a range of methods from simple regression models to multivariate approaches and various data reduction approaches such as Orthogonal Partial Least Squares regression (O-PLS), and deal with the high degree of autocorrelation within the data. Multiple testing and combining data across several studies are other challenges that should be addressed in the analysis
Projects may include, for example, developing and applying cross-platform and multi-omics approaches to help understand signals and pathways arising from omics analyses, and associated epidemiological data.
You will have a background in molecular epidemiology or biostatistics, with analytical and interpretative skills in omics data. Candidates will be interested in gaining/sharing knowledge and experience within and outside their domains.
Candidates who have not yet been officially awarded their PhD will be appointed as Research Assistant within the salary range £35,477 - £38,566 per annum.
The post is full time and fixed-term, for 30 months.
Interview date is to be determined.
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About Imperial College London
Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.
You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.
We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.
It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.
Please note that job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.
All Imperial employees are expected to follow the 7 principles of Imperial Expectations:
- Champion a positive approach to change and opportunity
- Communicate regularly and effectively within, and across, teams
- Consider the thoughts and expectations of others
- Deliver positive outcomes
- Encourage inclusive participation and eliminate discrimination
- Develop and grow skills and expertise
- Work in a planned and managed way
In addition to the above, employees are required to observe and comply with all College policies and regulations.
Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.
Athena SWAN Silver Award 2016
We renewed our Silver in the April 2016 submission round. Recognising advancement of gender equality.
Disability Confident leader
Imperial is a Disability Confident leader
Imperial is working in partnership with GIRES to promote respect and provide equal treatment for trans people