@article{Lin:2017:10.1016/j.pacs.2017.04.001,
author = {Lin, S and Shah, A and Hernández-Gil, J and Stanziola, A and Harriss, BI and Matsunaga, TO and Long, N and Bamber, J and Tang, M-X},
doi = {10.1016/j.pacs.2017.04.001},
journal = {Photoacoustics},
pages = {26--36},
title = {Optically and acoustically triggerable sub-micron phase-change contrast agents for enhanced photoacoustic and ultrasound imaging},
url = {http://dx.doi.org/10.1016/j.pacs.2017.04.001},
volume = {6},
year = {2017}
}

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TY  - JOUR
AB  - We demonstrate a versatile phase-change sub-micron contrast agent providing three modes of contrast enhancement: 1) photoacoustic imaging contrast, 2) ultrasound contrast with optical activation, and 3) ultrasound contrast with acoustic activation. This agent, which we name 'Cy-droplet', has the following novel features. It comprises a highly volatile perfluorocarbon for easy versatile activation, and a near-infrared optically absorbing dye chosen to absorb light at a wavelength with good tissue penetration. It is manufactured via a 'microbubble condensation' method. The phase-transition of Cy-droplets can be optically triggered by pulsed-laser illumination, inducing photoacoustic signal and forming stable gas bubbles that are visible with echo-ultrasound in situ. Alternatively, Cy-droplets can be converted to microbubble contrast agents upon acoustic activation with clinical ultrasound. Potentially all modes offer extravascular contrast enhancement because of the sub-micron initial size. Such versatility of acoustic and optical 'triggerability' can potentially improve multi-modality imaging, molecularly targeted imaging and controlled drug release.
AU  - Lin,S
AU  - Shah,A
AU  - Hernández-Gil,J
AU  - Stanziola,A
AU  - Harriss,BI
AU  - Matsunaga,TO
AU  - Long,N
AU  - Bamber,J
AU  - Tang,M-X
DO  - 10.1016/j.pacs.2017.04.001
EP  - 36
PY  - 2017///
SN  - 2213-5979
SP  - 26
TI  - Optically and acoustically triggerable sub-micron phase-change contrast agents for enhanced photoacoustic and ultrasound imaging
T2  - Photoacoustics
UR  - http://dx.doi.org/10.1016/j.pacs.2017.04.001
UR  - https://www.ncbi.nlm.nih.gov/pubmed/28507898
UR  - http://hdl.handle.net/10044/1/49514
VL  - 6
ER  - 

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