Citation

BibTex format

@inproceedings{Olofsson:2017:10.1016/B978-0-444-63965-3.50361-5,
author = {Olofsson, S and Mehrian, M and Geris, L and Calandra, R and Deisenroth, MP and Misener, R},
doi = {10.1016/B978-0-444-63965-3.50361-5},
pages = {2155--2160},
title = {Bayesian Multi-Objective Optimisation of Neotissue Growth in a Perfusion Bioreactor Set-Up},
url = {http://dx.doi.org/10.1016/B978-0-444-63965-3.50361-5},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - CPAPER
AB - © 2017 Elsevier B.V. We consider optimising bone neotissue growth in a 3D scaffold during dynamic perfusion bioreactor culture. The goal is to choose design variables by optimising two conflicting objectives: (i) maximising neotissue growth and (ii) minimising operating cost. Our contribution is a novel extension of Bayesian multi-objective optimisation to the case of one black-box (neotissue growth) and one analytical (operating cost) objective function, that helps determine, within a reasonable amount of time, what design variables best manage the trade-off between neotissue growth and operating cost. Our method is tested against and outperforms the most common approach in literature, genetic algorithms, and shows its important real-world applicability to problems that combine black-box models with easy-to-quantify objectives like cost.
AU - Olofsson,S
AU - Mehrian,M
AU - Geris,L
AU - Calandra,R
AU - Deisenroth,MP
AU - Misener,R
DO - 10.1016/B978-0-444-63965-3.50361-5
EP - 2160
PY - 2017///
SN - 1570-7946
SP - 2155
TI - Bayesian Multi-Objective Optimisation of Neotissue Growth in a Perfusion Bioreactor Set-Up
UR - http://dx.doi.org/10.1016/B978-0-444-63965-3.50361-5
ER -