Tranmission blocking vaccines
- Malaria Vaccine Initiative/Program for Appropriate Technology in Health
Working closely with laboratory and field scientists we are developing a variety of different mathematical models to identify the most effective transmission blocking vaccine candidate from laboratory data and predict its public health impact in different settings in Africa. The work will identify areas where the vaccine are likely to save the most lives or drive the parasite to elimination. These models shall also be used to help design clinical trials to evaluate the interventions in the field.
Delrieu I, Leboulleux D, Ivinson K, Gessner BD, Chandramohan D, Churcher T, Drakeley C, Halloran E, Killeen G, Kleinschmidt I, Milligan P, Robert V, Rogier C, Saul A, Sinden R, Smith Tet al., 2015, Design of a Phase III cluster randomized trial to assess the efficacy and safety of a malaria transmission blocking vaccine, VACCINE, Vol: 33, Pages: 1518-1526, ISSN: 0264-410X Publisher's link.
Wu Y, Sinden RE, Churcher TS, Tsuboi T, Yusibov Vet al., 2015, Development of Malaria Transmission-Blocking Vaccines: From Concept to Product, Editors: Rollinson, Stothard, Publisher: ELSEVIER ACADEMIC PRESS INC, Pages: 109-152, ISBN: 978-0-12-803301-2 Publisher's link.
Churcher TS, Bousema T, Walker M, Drakeley C, Schneider P, Ouedraogo AL, Basanez M-Get al., 2013, Predicting mosquito infection from Plasmodium falciparum gametocyte density and estimating the reservoir of infection, ELIFE, Vol: 2, ISSN: 2050-084X Publisher's link.