Transmission population assay
- Malaria Vaccine Initiative/Program for Appropriate Technology in Health
We are developing new laboratory and analytical tools to help evaluate the impact of transmission blocking interventions. These new drugs and vaccines aim to reduce the incidence of disease by impeding transmission from the human to the mosquito. This novel way of controlling malaria requires new methods for assessing the effectiveness of possible transmission blocking interventions. Together with the Department of Life Sciences and the Malaria Vaccine Initiative we have helped develop a population assay that mimics human-to-mosquito and mosquito-to-human transmission in a vertebrate laboratory population. These assays are being used to evaluate transmission blocking drugs and vaccines to allow the best candidates to be taken forward for human trials.
Da DF, Churcher TS, Yerbanga RS, Yameogo B, Sangare I, Ouedraogo JB, Sinden RE, Blagborough AM, Cohuet Aet al., 2015, Experimental study of the relationship between Plasmodium gametocyte density and infection success in mosquitoes; implications for the evaluation of malaria transmission-reducing interventions, EXPERIMENTAL PARASITOLOGY, Vol: 149, Pages: 74-83, ISSN: 0014-4894 Publisher's link.
Baragana B, Hallyburton I, Lee MCS, Norcross NR, Grimaldi R, Otto TD, Proto WR, Blagborough AM, Meister S, Wirjanata G, Ruecker A, Upton LM, Abraham TS, Almeida MJ, Pradhan A, Porzelle A, Santos Martinez M, Bolscher JM, Woodland A, Norval S, Zuccotto F, Thomas J, Simeons F, Stojanovski L, Osuna-Cabello M, Brock PM, Churcher TS, Sala KA, Zakutansky SE, Belen Jimenez-Diaz M, Maria Sanz L, Riley J, Basak R, Campbell M, Avery VM, Sauerwein RW, Dechering KJ, Noviyanti R, Campo B, Frearson JA, Angulo-Barturen I, Ferrer-Bazaga S, Javier Gamo F, Wyatt PG, Leroy D, Siegl P, Delves MJ, Kyle DE, Wittlin S, Marfurt J, Price RN, Sinden RE, Winzeler EA, Charman SA, Bebrevska L, Gray DW, Campbell S, Fairlamb AH, Willis PA, Rayner JC, Fidock DA, Read KD, Gilbert IHet al., 2015, A novel multiple-stage antimalarial agent that inhibits protein synthesis, NATURE, Vol: 522, Pages: 315-+, ISSN: 0028-0836 Publisher's link.
Upton LM, Brock PM, Churcher TS, Ghani AC, Gething PW, Delves MJ, Sala KA, Leroy D, Sinden RE, Blagborough AMet al., 2015, Lead Clinical and Preclinical Antimalarial Drugs Can Significantly Reduce Sporozoite Transmission to Vertebrate Populations, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Vol: 59, Pages: 490-497, ISSN: 0066-4804 Publisher's link.