Research & Publications

Most of the members of this group are from the Statistics Section and Biomaths research group of the Department of Mathematics. Below you can find a list of research areas that members of this group are currently working on and/or would like to work on by applying their developed mathematical and statistical methods.

Research areas

Research areas

Systems Biology

Statistical genomics and Epidemiology

Medical Imaging

Precision and Stratified Medicine

Analysis of clinical trials, observational and longitudinal studies

Infectious Disease Epidemiology

Publications

Citation

BibTex format

@article{Dopico:2015:10.1038/ncomms8000,
author = {Dopico, XC and Evangelou, M and Ferreira, RC and Guo, H and Pekalski, ML and Smyth, DJ and Cooper, N and Burren, OS and Fulford, AJ and Hennig, BJ and Prentice, AM and Ziegler, AG and Bonifacio, E and Wallace, C and Todd, JA},
doi = {10.1038/ncomms8000},
journal = {Nature Communications},
title = {Widespread seasonal gene expression reveals annual differences in human immunity and physiology},
url = {http://dx.doi.org/10.1038/ncomms8000},
volume = {6},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Seasonal variations are rarely considered a contributing component to human tissue function or health, although many diseases and physiological process display annual periodicities. Here we find more than 4,000 protein-coding mRNAs in white blood cells and adipose tissue to have seasonal expression profiles, with inverted patterns observed between Europe and Oceania. We also find the cellular composition of blood to vary by season, and these changes, which differ between the United Kingdom and The Gambia, could explain the gene expression periodicity. With regards to tissue function, the immune system has a profound pro-inflammatory transcriptomic profile during European winter, with increased levels of soluble IL-6 receptor and C-reactive protein, risk biomarkers for cardiovascular, psychiatric and autoimmune diseases that have peak incidences in winter. Circannual rhythms thus require further exploration as contributors to various aspects of human physiology and disease.
AU  - Dopico,XC
AU  - Evangelou,M
AU  - Ferreira,RC
AU  - Guo,H
AU  - Pekalski,ML
AU  - Smyth,DJ
AU  - Cooper,N
AU  - Burren,OS
AU  - Fulford,AJ
AU  - Hennig,BJ
AU  - Prentice,AM
AU  - Ziegler,AG
AU  - Bonifacio,E
AU  - Wallace,C
AU  - Todd,JA
DO  - 10.1038/ncomms8000
PY  - 2015///
SN  - 2041-1723
TI  - Widespread seasonal gene expression reveals annual differences in human immunity and physiology
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/ncomms8000
UR  - http://www.ncbi.nlm.nih.gov/pubmed/25965853
UR  - http://hdl.handle.net/10044/1/42450
VL  - 6
ER  -
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