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  • JOURNAL ARTICLE
    VANDIJK LC, KRAMS R, SIPKEMA P, WESTERHOF Net al., 1988,

    CHANGES IN CORONARY PRESSURE-FLOW RELATION AFTER TRANSITION FROM BLOOD TO TYRODE PERFUSION

    , AMERICAN JOURNAL OF PHYSIOLOGY, Vol: 255, Pages: H476-H482, ISSN: 0002-9513
  • JOURNAL ARTICLE
    Van Dijk LC, Krams R, Sipkema P, Westerhof Net al., 1988,

    Changes in coronary pressure-flow relation after transition from blood to Tyrode perfusion.

    , Am J Physiol, Vol: 255, Pages: H476-H482, ISSN: 0002-9513

    In six isolated, diastolic-arrested, maximally vasodilated cat hearts, we studied changes in coronary pressure-flow relations (zero-flow pressure intercept, resistance) during the first 25 min, after a change of perfusate, from blood to Tyrode. The apparent intercept (zero-flow) pressure changed from 2.0 +/- 0.94 (+/- SD) kPa during blood perfusion to 2.5 +/- 0.55, 2.6 +/- 0.68, 2.5 +/- 0.94, and 2.7 +/- 1.34 kPa during Tyrode perfusion for 2:15, 5:30, 10:30, and 25:00 min, respectively. Intercept pressures during Tyrode perfusion were significantly different from the intercept pressure during blood perfusion, except for the one measured after 25 min of Tyrode perfusion (P less than 0.05). Resistance (defined as the ratio of perfusion pressure and flow at 10 kPa perfusion pressure) steadily rose to approximately 170% of the value during blood perfusion. The observation that the apparent intercept pressure is maintained, when a particle-free (Newtonian) isotonic perfusate is used, may indicate that this intercept is not a result of blood rheology alone. The increase rather than decrease in resistance suggests an effect of edema, which increases interstitial volume at the expense of intravascular volume.

  • JOURNAL ARTICLE
    YIN F, SIPKEMA P, KRAMS R, STRUMPF R, RESAR Jet al., 1988,

    EFFECTS OF STRETCH ON THE PRESSURE-FLOW RELATION OF THE ISOLATED ARRESTED DOG SEPTUM

    , FASEB JOURNAL, Vol: 2, Pages: A302-A302, ISSN: 0892-6638
  • JOURNAL ARTICLE
    WESTERHOF N, KRAMS R, 1986,

    PRESSURE AND TONE DEPENDENCE OF CORONARY DIASTOLIC INPUT IMPEDANCE AND CAPACITANCE - COMMENT

    , AMERICAN JOURNAL OF PHYSIOLOGY, Vol: 250, Pages: H330-H330, ISSN: 0002-9513
  • JOURNAL ARTICLE
    Westerhof N, Krams R, 1986,

    Comments on "Pressure and tone dependence of coronary diastolic input impedance and capacitance".

    , Am J Physiol, Vol: 250, Pages: H330-H331, ISSN: 0002-9513
  • JOURNAL ARTICLE
    Westerhof N, Krams R, Canty JM, 1986,

    Comments on 'pressure and tone dependence of coronary diastolic input impedance and capacitance'

    , American Journal of Physiology - Heart and Circulatory Physiology, Vol: 250, ISSN: 0363-6135
  • JOURNAL ARTICLE
    KRAMS R, SIPKEMA P, WESTERHOF N, 1985,

    DOES LEFT-VENTRICULAR PRESSURE INFLUENCE THE CORONARY PRESSURE-FLOW RELATION IN THE CAT

    , JOURNAL OF PHYSIOLOGY-LONDON, Vol: 366, Pages: P42-P42, ISSN: 0022-3751
  • JOURNAL ARTICLE
    BORGDORFF P, BRAAKMAN R, VANHAELST ACTA, VANHUIS GA, DEJONG JP, KRAMS R, LANGEWOUTERS GJ, SIPKEMA P, WESTERHOF Net al., 1984,

    CONSISTENT PARALLEL RELATIONSHIPS AMONG MYOCARDIAL OXYGEN-CONSUMPTION, CORONARY BLOOD-FLOW, AND PERICARDIAL INFUSATE ADENOSINE CONCENTRATION WITH VARIOUS INTERVENTIONS AND BETA BLOCKADE IN THE DOG - COMMENT

    , CIRCULATION RESEARCH, Vol: 54, Pages: 348-348, ISSN: 0009-7330
  • JOURNAL ARTICLE
    Borgdorff P, Braakman R, van Haelst AC, van Huis GA, de Jong JP, Krams R, Langewouters GJ, Sipkema P, Westerhof Net al., 1984,

    "Consistent parallel relationships among myocardial oxygen consumption, coronary blood flow, and pericardial infusate adenosine concentration with various interventions and beta-blockade in the dog".

    , Circ Res, Vol: 54, ISSN: 0009-7330
  • JOURNAL ARTICLE
    Sipkema P, Burattini R, van Haelst ACTA, Krams R, Westerhof Net al., 1984,

    EFFECTS OF CARDIAC CONTRACTION ON CORONARY FLOW.

    , Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, ISSN: 0589-1019

    Coronary flow in isolated, maximally vasodilated, rabbit hearts (n equals 6) during isovolumic and isobaric contractions has been studied to investigate how cardiac contraction affects coronary flow. A Langendorff constant perfusion pressure system was used. A balloon mounted on a wide bore cannula was introduced into the left ventricle through the mitral valve opening. This system was filled with water and connected to a reservoir via a stopcock. The heart could be studied under isovolumic and isobaric conditions for various degrees of filling. It was found that in diastole coronary flow impediment increases with increasing diastolic left ventricular pressure.

  • JOURNAL ARTICLE
    WESTERHOF N, KRAMS R, VANHAELST ACTA, SIPKEMA Pet al., 1984,

    CAN LEFT-VENTRICULAR PRESSURE EXPLAIN CORONARY FLOW IMPEDIMENT

    , FEDERATION PROCEEDINGS, Vol: 43, Pages: 440-440, ISSN: 0014-9446
  • JOURNAL ARTICLE
    BRAAKMAN R, VANDERHORN GJ, VONHUIS GA, KRAMS R, LANGEWOUTERS GJ, SIPKEMA P, WESTERHOF Net al., 1982,

    THE EFFECTS OF THE CORONARY CAPACITANCE ON THE INTERPRETATION OF DIASTOLIC PRESSURE-FLOW RELATIONSHIPS - COMMENTS

    , CIRCULATION RESEARCH, Vol: 51, Pages: 822-822, ISSN: 0009-7330

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