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  • JOURNAL ARTICLE
    Jackson CL, Bennett MR, Biessen EAL, Johnson JL, Krams Ret al., 2007,

    Assessment of unstable atherosclerosis in mice

    , ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 27, Pages: 714-720, ISSN: 1079-5642
  • CONFERENCE PAPER
    Kis Z, Silaghi-Dumitrescu R, 2007,

    Fe(0) in proteins? The reactivity of myoglobin towards strong reducing agents

    , C.D. NeniĆŁescu Conference
  • JOURNAL ARTICLE
    Kofflard MJ, Michels M, Krams R, Kliffen M, Geleijnse ML, Ten Cate FJ, Serruys PWet al., 2007,

    Coronary flow reserve in hypertrophic cardiomyopathy: relation with microvascular dysfunction and pathophysiological characteristics

    , NETHERLANDS HEART JOURNAL, Vol: 15, Pages: 209-215, ISSN: 0929-7456
  • JOURNAL ARTICLE
    Segers D, Helderman F, Cheng C, van Damme LCA, Tempel D, Boersma E, Serruys PW, de Crom R, van der Steen AFW, Holvoet P, Krams Ret al., 2007,

    Gelatinolytic activity in atherosclerotic plaques is highly localized and is associated with both macrophages and smooth muscle cells in vivo

    , CIRCULATION, Vol: 115, Pages: 609-616, ISSN: 0009-7322
  • CONFERENCE PAPER
    Segers D, de Crom R, Leenen P, Pasterkamp G, Krams Ret al., 2007,

    The chemokine CXCL10 is involved in the development of atherosclerotic plaque vulnerability

    , 80th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 172-172, ISSN: 0009-7322
  • JOURNAL ARTICLE
    Susa D, van den Engel S, van Damme LA, Roest HP, Krams R, IJiermans JNM, De Bruin RWFet al., 2007,

    Donor pre-treatment with tacrolimus reduces transplant vasculopathy

    , TRANSPLANT INTERNATIONAL, Vol: 20, Pages: 141-141, ISSN: 0934-0874
  • JOURNAL ARTICLE
    Cheng C, Tempel D, van Haperen R, van der Baan A, Grosveld F, Daemen MJAP, Krams R, de Crom Ret al., 2006,

    Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress

    , CIRCULATION, Vol: 113, Pages: 2744-2753, ISSN: 0009-7322
  • JOURNAL ARTICLE
    Cheng C, Tempel D, van der Baan A, Krams R, Daemen MJAP, van Haperen R, Grosveld F, de Crom Ret al., 2006,

    Response to letter regarding article, "Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress"

    , CIRCULATION, Vol: 114, Pages: E615-E615, ISSN: 0009-7322
  • JOURNAL ARTICLE
    Frijlink ME, Goertz DE, Vos HJ, Tesselaar E, Blacquiere G, Gisolf A, Krams R, van der Steen AFWet al., 2006,

    Harmonic intravascular ultrasound imaging with a dual-frequency catheter

    , ULTRASOUND IN MEDICINE AND BIOLOGY, Vol: 32, Pages: 1649-1654, ISSN: 0301-5629
  • JOURNAL ARTICLE
    Frijlink ME, Goertz DE, van Damme LCA, Krams R, van der Steen AFWet al., 2006,

    Intravascular ultrasound tissue harmonic imaging in vivo

    , IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, Vol: 53, Pages: 1844-1852, ISSN: 0885-3010
  • JOURNAL ARTICLE
    Goertz DE, Frijlink ME, Tempel D, van Damme LCA, Krams R, Schaar JA, ten Cate FJ, Serruys PW, de Jong N, van der Steen AFWet al., 2006,

    Contrast harmonic intravascular ultrasound - A feasibility study for vasa vasorum imaging

    , INVESTIGATIVE RADIOLOGY, Vol: 41, Pages: 631-638, ISSN: 0020-9996
  • JOURNAL ARTICLE
    Krams R, Cheng C, Helderman F, Verheye S, van Damme LCA, Mousavi Gourabi B, Tempel D, Segers D, de Feyter P, Pasterkamp G, De Klein D, de Crom R, van der Steen AFW, Serruys PWet al., 2006,

    Shear stress is associated with markers of plaque vulnerability and MMP-9 activity.

    , EuroIntervention, Vol: 2, Pages: 250-256, ISSN: 1774-024X

    BACKGROUND: Vulnerable plaque has been associated with local macrophage accumulation and local high matrix metalloproteinase-2 (MMP-2) and MMP-9 activity. Since shear stress is a known local modulator of plaque location, we have determined whether local shear stress was associated with local plaque composition and with local MMP activity. METHODS AND RESULTS: In 17 NZW rabbits plaque was generated by denudation of the infrarenal aorta over a region of 5 cm and feeding them a high cholesterol diet for 2 months. After 2 months, a motorised IVUS pullback of the infrarenal aorta was performed with a 40 MHz IVUS catheter (CVIS, Boston Scientific, USA). IVUS derived vessel wall-lumen contours were reconstructed in 3D with in-house developed software. These reconstructions served as an input for a computational fluid dynamics technique, from which the 3-D shear stress field was calculated. Plaque regions were divided in 5 regions (n=8) to identify the location of highest macrophage accumulation or selected on basis of shear stress to identify whether high shear stress selects macrophage accumulation (n=8). In a second series, shear stress values were used to select regions -containing both latent and active MMP-2 and MMP-9. Segments were sectioned with a microtome and stained for smooth muscle cells (SMC), macrophages (MPhi) and collagen (COL). MPhi, displayed the highest density upstream of the plaque (6.9+/-2.4%, p<0.05), while SMC accumulated downstream (74.8+/-1.9%) of the plaque. High shear stress was associated with MPhi accumulation and MMP-9 activity (p<0.05). CONCLUSION: Upstream location of macrophages in plaques is associated with high shear stress and MMP-9 accumulation. These findings are discussed in relation to rheological theories reported previously in atherosclerosis.

  • JOURNAL ARTICLE
    Krams R, Schaar J, Helderman F, Cheng C, Gourabi BM, Van Damme LCA, Segers D, Regar E, Slager CJ, De Feyter PJ, Van Der Steen AFW, Serruys PWet al., 2006,

    Visualization of the vulnerable plaque

    , Pages: 221-234

    Thrombosis is the main cause of acute coronary syndrome and myocardial infarction (Naghavi et al., 2003). The mechanism underlying thrombus formation is presently under debate, but several pathological conditions have been identified from human postmortem studies that correspond with the presence of thrombus. Of these conditions plaque rupture is the most common, but erosion of the endothelial layer and existence of calcified nodules without the existence of plaque rupture have also been identified. Plaques that have been ruptured have certain features in common (Falk, 1999; Virmani et al., 2002): (i) size of the lipid core (40% of the entire plaque), (ii) thickness of the fibrous cap (less than 65 μm), (iii) presence of inflammatory cells, (iv) amount of remodeling and extent of plaque-free vessel wall. Several terms have been identified focusing either on the pathological aspects (thin-cap fibroatheroma) or on the possibility to rupture (rupture-prone plaques) or on the possibility to induce thrombosis (vulnerable plaque). As vulnerable plaque is the term encompassing all other terms, therefore this term will be used throughout the chapter. © 2006 Springer Science+Business Media, Inc.

  • CONFERENCE PAPER
    Lipton J, Segers D, Cheng C, Duckers H, Krams R, Tempel D, Busser E, De Kleijn D, Moll FL, Pasterkamp Get al., 2006,

    High IP-10 levels identify plaques with a vulnerable phenotype

    , 79th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 287-288, ISSN: 0009-7322
  • JOURNAL ARTICLE
    Nette RW, Ie EHY, Vletter WB, Krams R, Weimar W, Zietse Ret al., 2006,

    Norepinephrine-induced vasoconstriction results in decreased blood volume in dialysis patients

    , NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol: 21, Pages: 1305-1311, ISSN: 0931-0509

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