MRC studentships

Awarded to high calibre researchers for projects in the area of Informatics for Health and Digital Technologies

Imperial College London invites applications from outstanding applicants looking to pursue a PhD in the area of Informatics for Health and Digital Technologies.   Successful students will be expected to begin the PhD no later than October 2017.

The scale and complexity of biomedical and health data is increasing through a variety of sources, including large population and cohort studies, high-throughput ‘omics’ platforms, imaging, and mobile, patient centred technologies. Bringing these and other data together for analysis and interpretation offers unprecedented opportunities to advance understanding of the causes, prevention and treatment of disease.

These studentships are offered with Medical Research Council (MRC) support and will be based in either the MRC Centre for Molecular Bacteriology and Infection (CMBI), the MRC Centre for Outbreak Analysis and Modelling (COAM), the MRC-PHE Centre for Environment and Health (PHE), the MRC-NIHR Phenome Centre (NPC), the UK Dementia Research Institute (UK DRI) or the MRC Doctoral Training Partnership (DTP).

Imperial MRC students benefit from additional support and funding through the MRC Supplement Scheme.

The application deadline for these studentships is 23:59 GMT on 31 July 2017.  Successful students will be expected to begin the PhD no later than October 2017.

Projects list

The following are examples of the type of projects that will be available to successful students.  Final choices will be made in discussion between students and Centres.

Projects list

Project examples - MRC Centre for Molecular Bacteriology and Infection

High-throughput comparative and functional genomic analysis of type IV pilus (Tfp) localised adhesins in the opportunistic human pathogen Streptococccus sanguinis. Understanding how Tfp, a universal bacterial virulence factor, mediate adhesion to host cells.
Investigation of the effects of toxins on transcriptomes during persister formation
Development of a bioinformatics platform and database for an automatic and simple identification of Enterobacteriacae resistant to the last resort antibiotic using MALDI mass spectrometry
Host transcriptomics of pathogenesis and recovery from infection
Surface proteomic analysis of bacterially infected intestinal epithelial cells

Project examples - MRC Centre for Outbreak Analysis and Modelling

Modelling optimal efficacy trial designs for arboviral vaccines
Predicting the efficacy and public health impact of second generation malaria vaccines
Developing models to support Target Product Profile (TPP) development of new anti-malarial drugs

Project examples - MRC-PHE Centre for Environment & Health

Worldwide phenotypes of multiple cardiometabolic risk factors
Heavy metal body burden and health in the Newcastle Thousand Families birth cohort
Using the distributed lag models to assess the effect of environmental exposures on health in a spatio-temporal framework
Cardiovascular risk factors and cognitive decline

Project examples - MRC UK Dementia Research Institute

Metabolomic markers of cognitive decline in a large occupational cohort.
Therapeutic modulation of amyloid beta clearance from the brain during sleep
Non-invasive, targeted bioelectronic brain modulation for cognitive enhancement 

Project examples - MRC Doctoral Training Partnership

Statistical Issues in Over-fitting in Predictive Models Produced for Stratified Medicine
Development of Nasal Lipidomics during Viral Infections
Drug-induced metabolic signatures of resistance in cancer cells 
Integrated analysis of known metabolic networks and metabolomics & transcriptomic profiles in cancer models