Below are some examples of previous project titles made available for students who chose the Biomedical Research stream within the MRes in Biomedical Research. Please note that these are just for reference, and availability of projects is subject to change each year. 

  • Determination of the Mechanisms by Which Resistance to Endocrine Therapies Arises in Breast Cancer Using Model Breast Cancer Cell Lines
  • The Role of JAKs and STATs in Chemoresistance
  • Global Optimisation of peak detection and alignment procedures in liquid chromatography – mass spectrometry for metabolomics
  • Effect of PMCA inhibitory peptides on functional and signalling events in platelets
  • Activation of cardiac trabecular muscle by photolytic release of calcium from a  'caged calcium' compound
  • Skeletal muscle fibre performance following myosin essential light chain exchange
  • FRET signal characterization in skeletal muscle fibres
  • The role of gene-body methylation in breast carcinogenesis
  • Selected Ion Flow Tube-Mass Spectrometric analysis of the volatile organic compounds released by different bacteria
  • Expression of Adhesion Molecules in Follicles in the Mammalian Ovary
  • The role of cobalt ions in inflammatory pathology following hip replacements
  • The role of isoprenylation of RabGTPases in leukocyte chemotaxis and secretion
  • Inflammatory markers in airway disease
  • Regulation of smooth muscle life, death and phenotype by the protein Twist
  • Regulation of microRNA gene expression in response contractile activity
  • Using metabonomics to investigate metabolism during tumour development in the chick chorioallantoic membrane
  • The role of the tumour suppressor OPCML in attenuating Eph receptor-tyrosine kinases
  • Novel strategy promoting wound healing in vitro
  • Prediction of Pregnancy Outcomes using Metabolic Profiling
  • Analysis of DNA methylation and epigenetic regulation of the Wnt pathway in Ovarian Cancer
  • A Metabolomic and Systems Biology Perspective on the Fragile X Syndrome Mouse Model
  • A Predictive Metabolomic Signature Associated with Obesity Sub-Phenotypes in the Mouse
  • Systems Biology of Diabetes and Hypertension Metabolic Profiles in the Rat
  • A Metabolomic Genome-Wide Association Study of Cardio-Metabolic Syndrome in a Lebanese Population
  • Does TNF receptor subtype signalling vary between organs?
  • Employing 15N-NMR to understand bacterial adaptation and tolerance of nutrient limitation
  • Phenotypic analysis of clonal lineages of Pseudomonas aeruginosa from longitudinal cystic fibrosis infections
  • A Metabonomic Study of Paracetamol Hepatotoxicity
  • The biochemical component analysis of medicinal plant extracts
  • Identification of regulators of cell-cell junctions using RNAi screen and quantitative image analysis
  • The interplay of discoidin domain receptors and integrins in cell adhesion and migration
  • The role of the juxtamembrane domains in transmembrane signalling by the receptor tyrosine kinases DDR1 and DDR2
  • Analysing the mechanism of DDR activation using different preparations of collagen
  • Novel pathways in blood vessel formation: the transcription factor Erg regulates endothelial cell migration
  • Investigating the neurophysiology of the quadriceps during knee extension
  • Endo180: paving the way to malignancy
  • Impact of extracellular matrix stiffness on Endo180-mediated cell migration
  • What is the role of the SUMO pathway in regulating PR and  NF-kB signalling in human labour
  • Direct Effects of xenon on ATP-Sensitive K+ channels: elucidating molecular mechanisms
  • Identification and functional manipulation of GLP-1 releasing neurons of mouse brainstem to elucidate their role in feeding behaviour
  • Metabolic profiling of ASS1 negative vs ASS1 positive human Glioblastoma multiforme (GBM) cell lines
  • Identification of protein kinases involved in the anti-inflammatory response
  • DNA quadruplexes as novel therapeutic targets for cardiovascular disease
  • Investigation of the role of innate immunity and bacterial infections in the mosquito longevity and fitness
  • Susceptibility to fungal infection following influenza virus
  • Metabolic profiling of Leishmania major effects in murine tissue comparing different inocula - total promastigotes vs.purified metacyclics
  • The role of IL-8 in platinum resistance in ovarian cancer

Details about the research projects available in the upcoming year are made available upon starting the course.