@article{Salehi-Reyhani:2017:10.1177/1535370217711441,
author = {Salehi-Reyhani, A and Ces, O and Elani, Y},
doi = {10.1177/1535370217711441},
journal = {Experimental Biology and Medicine},
pages = {1309--1317},
title = {Artificial cell mimics as simplified models for the study of cell biology},
url = {http://dx.doi.org/10.1177/1535370217711441},
volume = {242},
year = {2017}
}

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TY  - JOUR
AB  - Living cells are hugely complex chemical systems composed of a milieu of distinct chemical species (including DNA, proteins, lipids, and metabolites) interconnected with one another through a vast web of interactions: this complexity renders the study of cell biology in a quantitative and systematic manner a difficult task. There has been an increasing drive towards the utilization of artificial cells as cell mimics to alleviate this, a development that has been aided by recent advances in artificial cell construction. Cell mimics are simplified cell-like structures, composed from the bottom-up with precisely defined and tunable compositions. They allow specific facets of cell biology to be studied in isolation, in a simplified environment where control of variables can be achieved without interference from a living and responsive cell. This mini-review outlines the core principles of this approach and surveys recent key investigations that use cell mimics to address a wide range of biological questions. It will also place the field in the context of emerging trends, discuss the associated limitations, and outline future directions of the field.
AU  - Salehi-Reyhani,A
AU  - Ces,O
AU  - Elani,Y
DO  - 10.1177/1535370217711441
EP  - 1317
PY  - 2017///
SN  - 1535-3702
SP  - 1309
TI  - Artificial cell mimics as simplified models for the study of cell biology
T2  - Experimental Biology and Medicine
UR  - http://dx.doi.org/10.1177/1535370217711441
UR  - http://hdl.handle.net/10044/1/48385
VL  - 242
ER  - 

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