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Journal articleJervis P, Pintanel P, Hopkins K, et al., 2021,
Post‐epizootic microbiome associations across communities of neotropical amphibians
, Molecular Ecology, Vol: 30, Pages: 1322-1335, ISSN: 0962-1083Microbiome–pathogen interactions are increasingly recognized as an important element of host immunity. While these host‐level interactions will have consequences for community disease dynamics, the factors which influence host microbiomes at larger scales are poorly understood. We here describe landscape‐scale pathogen–microbiome associations within the context of post‐epizootic amphibian chytridiomycosis, a disease caused by the panzootic chytrid fungus Batrachochytrium dendrobatidis. We undertook a survey of Neotropical amphibians across altitudinal gradients in Ecuador ~30 years following the observed amphibian declines and collected skin swab‐samples which were metabarcoded using both fungal (ITS‐2) and bacterial (r16S) amplicons. The data revealed marked variation in patterns of both B. dendrobatidis infection and microbiome structure that are associated with host life history. Stream breeding amphibians were most likely to be infected with B. dendrobatidis. This increased probability of infection was further associated with increased abundance and diversity of non‐Batrachochytrium chytrid fungi in the skin and environmental microbiome. We also show that increased alpha diversity and the relative abundance of fungi are lower in the skin microbiome of adult stream amphibians compared to adult pond‐breeding amphibians, an association not seen for bacteria. Finally, stream tadpoles exhibit lower proportions of predicted protective microbial taxa than pond tadpoles, suggesting reduced biotic resistance. Our analyses show that host breeding ecology strongly shapes pathogen–microbiome associations at a landscape scale, a trait that may influence resilience in the face of emerging infectious diseases.
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Journal articleMullish BH, Quraishi MN, Segal JP, et al., 2021,
The gut microbiome: what every gastroenterologist needs to know
, Frontline Gastroenterology, Vol: 12, Pages: 118-127, ISSN: 2041-4137<jats:p>The mucosal surfaces of the body are characterised by complex, specialised microbial communities, often referred to as the<jats:italic>microbiome</jats:italic>. However, only much more recently—with the development of technologies allowing exploration of the composition and functionality of these communities—has meaningful research in this area become feasible. Over the past few years, there has been rapid growth in interest in the gut microbiome in particular, and its potential contribution to gastrointestinal and liver disease. This interest has already extended beyond clinicians to pharmaceutical companies, medical regulators and other stakeholders, and is high profile among patients and the lay public in general. Such expansion of knowledge holds the intriguing potential for translation into novel diagnostics and therapeutics; however, being such a nascent field, there remain many uncertainties, unanswered questions and areas of debate.</jats:p>
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Journal articleAllegretti JR, Kassam Z, Hurtado J, et al., 2021,
Impact of fecal microbiota transplantation with capsules on the prevention of metabolic syndrome among patients with obesity
, HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM, Vol: 20, Pages: 209-211, ISSN: 1109-3099- Author Web Link
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- Citations: 20
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Conference paperGhani R, Mullish B, Innes A, et al., 2021,
Faecal microbiota transplant (FMT) prior to allogeneic haematopoietic cell transplantation (HCT) in patients colonised with multidrug-resistant organisms (MDRO) results in improved survival
, ECCMID -
ReportNICE, 2021,
Faecal microbiota transplant for recurrent or refractory Clostridioides difficile infection
, Medtech innovation briefing [MIB247] -
Journal articleLetertre MPM, Myridakis A, Whiley L, et al., 2021,
A targeted ultra performance liquid chromatography - Tandem mass spectrometric assay for tyrosine and metabolites in urine and plasma: Application to the effects of antibiotics on mice
, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, Vol: 1164, ISSN: 1570-0232- Author Web Link
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- Citations: 5
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ReportMorgan A, Vander Broek C, 2021,
Microbiome Strategic Roadmap
, Publisher: KTN -
Conference paperMonaghan T, Russell L, Rosati E, et al., 2021,
P307 FMT-associated alterations in the TCR repertoire of patients with severe or fulminant Clostridioides difficile infection
, BSG Campus, Publisher: BMJ Publishing Group, Pages: A199-A200, ISSN: 0017-5749 -
Journal articleMichael DR, Davies TS, Jack AA, et al., 2020,
Daily supplementation with the Lab4P probiotic consortium induces significant weight loss in overweight adults
, Scientific Reports, Vol: 11<jats:title>Abstract</jats:title><jats:p>This 9-month randomised, parallel, double-blind, single-centre, placebo-controlled study (PROBE, ISRCTN18030882) assessed the impact of probiotic supplementation on bodyweight. Seventy overweight Bulgarian participants aged 45–65 years with BMI 25–29.9 kg/m<jats:sup>2</jats:sup> received a daily dose of the Lab4P probiotic comprising lactobacilli and bifidobacteria (50 billion cfu/day). Participants maintained their normal diet and lifestyle over the duration of the study. The primary outcome was change from baseline in body weight and secondary outcomes included changes in waist circumference, hip circumference and blood pressure. A significant between group decrease in body weight (3.16 kg, 95% CI 3.94, 2.38, <jats:italic>p</jats:italic> < 0.0001) was detected favouring the probiotic group. Supplementation also resulted in significant between group decreases in waist circumference (2.58 cm, 95% CI 3.23, 1.94, <jats:italic>p</jats:italic> < 0.0001) and hip circumference (2.66 cm, 95% CI 3.28, 2.05, <jats:italic>p</jats:italic> < 0.0001) but no changes in blood pressure were observed. These findings support the outcomes of a previous shorter-term Lab4P intervention study in overweight and obese participants (PROMAGEN, ISRCTN12562026). We conclude that Lab4P has consistent weight modulation capability in free-living overweight adults.</jats:p>
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Journal articleHuus KE, Frankowski M, Pučić-Baković M, et al., 2021,
Changes in IgA-targeted microbiota following fecal transplantation for recurrent <i>Clostridioides difficile</i> infection
, Gut Microbes, Vol: 13, ISSN: 1949-0976
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