Citation

BibTex format

@article{Pean:2017:10.1038/ncomms14642,
author = {Pean, CB and Schiebler, M and Tan, S and Sharrock, J and Kierdorf, K and Brown, K and Maserumule, M and Menezes, S and Platova, M and Bronda, K and Guermonprez, P and Stramer, BM and Floto, R and Dionne, MS},
doi = {10.1038/ncomms14642},
journal = {Nature Communications},
title = {Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection},
url = {http://dx.doi.org/10.1038/ncomms14642},
volume = {8},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Mycobacterium tuberculosis remains a global threat to human health yet the molecular mechanisms regulating immunity remain poorly understood. Cytokines can promote or inhibit mycobacterial survivalinside macrophages, andthe underlying mechanisms represent potential targets for host-directed therapies. Here we show that cytokine-STAT signaling promotesmycobacterial survivalwithin macrophages by deregulating lipid droplets via ATG2 repression. In Drosophilainfected withMycobacterium marinum,mycobacterium-induced STAT activitytriggered by unpaired-familycytokinesreduces Atg2 expression, permittingderegulation of lipid droplets. Increased Atg2expression, or reduced macrophage triglyceride biosynthesis,normalizes lipid deposition in infected phagocytes and reduces numbersof viable intracellular mycobacteria. In human macrophages,addition ofIL-6promotes mycobacterial survival and BCG-induced lipid accumulation by a similar, but probably not identical, mechanism. Our results reveal Atg2regulation as amechanism by which cytokines can control lipid droplet homeostasis and consequently resistance to mycobacterial infectionin Drosophila.
AU - Pean,CB
AU - Schiebler,M
AU - Tan,S
AU - Sharrock,J
AU - Kierdorf,K
AU - Brown,K
AU - Maserumule,M
AU - Menezes,S
AU - Platova,M
AU - Bronda,K
AU - Guermonprez,P
AU - Stramer,BM
AU - Floto,R
AU - Dionne,MS
DO - 10.1038/ncomms14642
PY - 2017///
SN - 2041-1723
TI - Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection
T2 - Nature Communications
UR - http://dx.doi.org/10.1038/ncomms14642
UR - http://hdl.handle.net/10044/1/44135
VL - 8
ER -