Citation

BibTex format

@article{Lee:2017:10.1038/s41467-017-01676-0,
author = {Lee, PP and Lobato-Marquez, D and Pramanik, N and Sirianni, A and Daza-Cajigal, V and Rivers, E and Cavazza, A and Bouma, G and Moulding, D and Hultenby, K and Westerberg, LS and Hollinshead, M and Lau, Y-L and Burns, SO and Mostowy, S and Bajaj-Elliott, M and Thrasher, AJ},
doi = {10.1038/s41467-017-01676-0},
journal = {Nature Communications},
title = {Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells},
url = {http://dx.doi.org/10.1038/s41467-017-01676-0},
volume = {8},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Dysregulation of autophagy and inflammasome activity contributes to the development of auto-inflammatory diseases. Emerging evidence highlights the importance of the actin cytoskeleton in modulating inflammatory responses. Here we show that deficiency of Wiskott–Aldrich syndrome protein (WASp), which signals to the actin cytoskeleton, modulates autophagy and inflammasome function. In a model of sterile inflammation utilizing TLR4 ligation followed by ATP or nigericin treatment, inflammasome activation is enhanced in monocytes from WAS patients and in WAS-knockout mouse dendritic cells. In ex vivo models of enteropathogenic Escherichia coli and Shigella flexneri infection, WASp deficiency causes defective bacterial clearance, excessive inflammasome activation and host cell death that are associated with dysregulated septin cage-like formation, impaired autophagic p62/LC3 recruitment and defective formation of canonical autophagosomes. Taken together, we propose that dysregulation of autophagy and inflammasome activities contribute to the autoinflammatory manifestations of WAS, thereby identifying potential targets for therapeutic intervention.
AU - Lee,PP
AU - Lobato-Marquez,D
AU - Pramanik,N
AU - Sirianni,A
AU - Daza-Cajigal,V
AU - Rivers,E
AU - Cavazza,A
AU - Bouma,G
AU - Moulding,D
AU - Hultenby,K
AU - Westerberg,LS
AU - Hollinshead,M
AU - Lau,Y-L
AU - Burns,SO
AU - Mostowy,S
AU - Bajaj-Elliott,M
AU - Thrasher,AJ
DO - 10.1038/s41467-017-01676-0
PY - 2017///
SN - 2041-1723
TI - Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells
T2 - Nature Communications
UR - http://dx.doi.org/10.1038/s41467-017-01676-0
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000415648900008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/55672
VL - 8
ER -