Auner Lab

Contact


Dr Holger Auner

  • CRUK Advanced Clinician Scientist
  • Clinical Reader in Molecular Haemato-Oncology

+44 (0)20 3313 4017
holger.auner04@imperial.ac.uk

Areas of research


Proteotoxic stress and metabolism

Myeloma cells are characterised by a unique sensitivity to inhibitors of the proteasome, which is responsible for the controlled degradation of most cellular proteins that have become damaged or are otherwise unwanted. Nevertheless, resistance to proteasome inhibitors occurs in essentially all patients to varying degrees. Accumulation of misfolded proteins in the endoplasmic reticulum (ER), which triggers proteotoxic ‘ER stress’, is widely believed to be the main mechanism of action of proteasome inhibitors. However, data from our lab and other research groups suggest complex interactions between proteasomal protein degradation and multiple metabolic processes. Our aim is to find metabolic and proteostatic vulnerabilities that we can exploit therapeutically.


Tissue biophysics in myeloma biology

Several important aspects of cancer cell biology are influenced by mechanical cues from the surrounding tissue. In particular, mechanical interactions and matrix remodelling have been shown to govern cancer cell metabolism. Tissue stiffness also impacts on normal haematopoiesis, and mechanical cues are known to modulate therapeutic responses. Moreover, we have shown that proteostasis-targeting drugs can alter tissue physical properties. We aim to understand how tissue stiffness and nutrient availability act together to rewire metabolic networks and regulate drug responses in myeloma.


Citation

BibTex format

@inproceedings{Garderet:2018,
author = {Garderet, L and Sbianchi, G and van, der Werf S and Blaise, D and Russell, N and Auner, H and Chevallier, P and Nahi, H and Remenyi, P and Yakoub-Agha, I and Isaksson, C and Krejci, M and Browne, P and Lenhoff, S and Soledad, Gonzalez M and Parody, Porras R and Wiktor-Jedrzejczak, W and Wilson, KMO and Trneny, M and Poire, X and Passweg, J and Jantunen, E and Jost, E and Schoenland, S and Kroeger, N},
pages = {650--651},
publisher = {NATURE PUBLISHING GROUP},
title = {Impact of induction regimen duration before autologous stem cell transplantation in myeloma},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000487702806080&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - CPAPER
AU - Garderet,L
AU - Sbianchi,G
AU - van,der Werf S
AU - Blaise,D
AU - Russell,N
AU - Auner,H
AU - Chevallier,P
AU - Nahi,H
AU - Remenyi,P
AU - Yakoub-Agha,I
AU - Isaksson,C
AU - Krejci,M
AU - Browne,P
AU - Lenhoff,S
AU - Soledad,Gonzalez M
AU - Parody,Porras R
AU - Wiktor-Jedrzejczak,W
AU - Wilson,KMO
AU - Trneny,M
AU - Poire,X
AU - Passweg,J
AU - Jantunen,E
AU - Jost,E
AU - Schoenland,S
AU - Kroeger,N
EP - 651
PB - NATURE PUBLISHING GROUP
PY - 2018///
SN - 0268-3369
SP - 650
TI - Impact of induction regimen duration before autologous stem cell transplantation in myeloma
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000487702806080&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
ER -