Citation

BibTex format

@article{Varghese:2021:10.1002/cmdc.202000399,
author = {Varghese, S and Rahmani, R and Drew, DR and Beeson, JG and Baum, J and Smith, BJ and Baell, J},
doi = {10.1002/cmdc.202000399},
journal = {ChemMedChem},
pages = {679--693},
title = {Structure activity studies of truncated latrunculin analogues with anti-malarial activity},
url = {http://dx.doi.org/10.1002/cmdc.202000399},
volume = {16},
year = {2021}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Malarial parasites employ actin dynamics for motility, and any disruption to these dynamics renders the parasites unable to effectively establish infection. Therefore, actin presents a potential target for malarial drug discovery, and naturally occurring actin inhibitors such as latrunculins are a promising starting point. However, the limited availability of the natural product and the laborious route for synthesis of latrunculins have hindered their potential development as drug candidates. In this regard, we recently described novel truncated latrunculins, with superior actin binding potency and selectivity towards P. falciparum actin than the canonical latrunculin B. In this paper, we further explore the truncated latrunculin core to summarize the SAR for inhibition of malaria motility. This study helps further understand the binding pattern of these analogues in order to develop them as drug candidates for malaria.
AU - Varghese,S
AU - Rahmani,R
AU - Drew,DR
AU - Beeson,JG
AU - Baum,J
AU - Smith,BJ
AU - Baell,J
DO - 10.1002/cmdc.202000399
EP - 693
PY - 2021///
SN - 0014-827X
SP - 679
TI - Structure activity studies of truncated latrunculin analogues with anti-malarial activity
T2 - ChemMedChem
UR - http://dx.doi.org/10.1002/cmdc.202000399
UR - https://www.ncbi.nlm.nih.gov/pubmed/32929894
UR - https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202000399
UR - http://hdl.handle.net/10044/1/83598
VL - 16
ER -