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  • JOURNAL ARTICLE
    Chan TG, Morse SV, Copping MJ, Choi JJ, Vilar Ret al., 2018,

    Targeted Delivery of DNA-Au Nanoparticles across the Blood-Brain Barrier Using Focused Ultrasound

    , CHEMMEDCHEM, Vol: 13, Pages: 1311-1314, ISSN: 1860-7179
  • JOURNAL ARTICLE
    Dall'Orso S, Steinweg J, Allievi AG, Edwards AD, Burdet E, Arichi Tet al., 2018,

    Somatotopic Mapping of the Developing Sensorimotor Cortex in the Preterm Human Brain

    , CEREBRAL CORTEX, Vol: 28, Pages: 2507-2515, ISSN: 1047-3211
  • JOURNAL ARTICLE
    Lubba CH, Le Guen Y, Jarvis S, Jones NS, Cork SC, Eftekhar A, Schultz SRet al., 2018,

    PyPNS: Multiscale Simulation of a Peripheral Nerve in Python.

    , Neuroinformatics

    Bioelectronic Medicines that modulate the activity patterns on peripheral nerves have promise as a new way of treating diverse medical conditions from epilepsy to rheumatism. Progress in the field builds upon time consuming and expensive experiments in living organisms. To reduce experimentation load and allow for a faster, more detailed analysis of peripheral nerve stimulation and recording, computational models incorporating experimental insights will be of great help. We present a peripheral nerve simulator that combines biophysical axon models and numerically solved and idealised extracellular space models in one environment. We modelled the extracellular space as a three-dimensional resistive continuum governed by the electro-quasistatic approximation of the Maxwell equations. Potential distributions were precomputed in finite element models for different media (homogeneous, nerve in saline, nerve in cuff) and imported into our simulator. Axons, on the other hand, were modelled more abstractly as one-dimensional chains of compartments. Unmyelinated fibres were based on the Hodgkin-Huxley model; for myelinated fibres, we adapted the model proposed by McIntyre et al. in 2002 to smaller diameters. To obtain realistic axon shapes, an iterative algorithm positioned fibres along the nerve with a variable tortuosity fit to imaged trajectories. We validated our model with data from the stimulated rat vagus nerve. Simulation results predicted that tortuosity alters recorded signal shapes and increases stimulation thresholds. The model we developed can easily be adapted to different nerves, and may be of use for Bioelectronic Medicine research in the future.

  • JOURNAL ARTICLE
    Quicke P, Reynolds S, Neil M, Knopfel T, Schultz SR, Foust AJet al., 2018,

    High speed functional imaging with source localized multifocal two-photon microscopy

    , BIOMEDICAL OPTICS EXPRESS, Vol: 9, ISSN: 2156-7085
  • CONFERENCE PAPER
    Morse SV, Pouliopoulos AN, Chan T, Lin J, Copping M, Long NJ, Choi JJet al., 2017,

    Rapid short-pulse (RaSP) sequences improve the distribution of drug delivery to the brain in vivo

    , ISSN: 1948-5719

    © 2017 IEEE. Focused ultrasound and microbubbles have been shown to locally and noninvasively open the blood-brain barrier. Despite encouraging results in human patients, several performance and safety features, such as poor drug distribution, high drug accumulation along vessels and small sites of red blood cell extravasation, have been unavoidable. We have recently developed a new ultrasound sequence - rapid short-pulse (RaSP) sequence - designed to suppress these adverse features by promoting safer modes of cavitation activity throughout capillaries. In our RaSP sequences, low-pressure short ultrasonic pulses are emitted at kHz pulse repetition frequencies (PRF) and grouped into bursts. We have shown in vitro that RaSP sequences prolong microbubble lifetime and increase their mobility, enhancing the distribution of acoustic cavitation activity. Here we evaluate the ability of RaSP sequences to improve the in vivo performance and safety of ultrasound-mediated drug delivery to the brain.

  • JOURNAL ARTICLE
    Quicke P, Barnes SJ, Knöpfel T, 2017,

    Imaging of Brain Slices with a Genetically Encoded Voltage Indicator.

    , Methods Mol Biol, Vol: 1563, Pages: 73-84

    Functional fluorescence microscopy of brain slices using voltage sensitive fluorescent proteins (VSFPs) allows large scale electrophysiological monitoring of neuronal excitation and inhibition. We describe the equipment and techniques needed to successfully record functional responses optical voltage signals from cells expressing a voltage indicator such as VSFP Butterfly 1.2. We also discuss the advantages of voltage imaging and the challenges it presents.

  • JOURNAL ARTICLE
    Schultz SR, Copeland CS, Foust AJ, Quicke P, Schuck Ret al., 2017,

    Advances in Two-Photon Scanning and Scanless Microscopy Technologies for Functional Neural Circuit Imaging

    , PROCEEDINGS OF THE IEEE, Vol: 105, Pages: 139-157, ISSN: 0018-9219
  • CONFERENCE PAPER
    Schuck R, Quicke P, Copeland C, Garasto S, Annecchino LA, Hwang JK, Schultz SRet al., 2015,

    Rapid three dimensional two photon neural population scanning

    , 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Publisher: IEEE, Pages: 5867-5870, ISSN: 1557-170X

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